Changes in the Brain Extracellular Matrix Composition in schizophrenia: A Pathophysiological Dysregulation and a Potential Therapeutic Target.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-021-01073-8
Abstract: The brain extracellular matrix (ECM) is involved in crucial processes of neural support, neuronal and synaptic plasticity, extrasynaptic transmission, and neurotransmission. ECM is a tridimensional fibrillary meshwork composed of macromolecules that determine its bioactivity and… read more here.
Keywords: brain ecm; extracellular matrix; brain extracellular; pathophysiological dysregulation ... See more keywords
Online profiling of living rat brain extracellular pH using a pH-Dependent solid phase extraction scheme coupled with microdialysis sampling and inductively coupled plasma mass spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2018.12.020
Abstract: In this study, a novel analytical method was developed for online profiling of living rat brain extracellular pH. It involved microdialysis (MD) sampling, introduction of metal ions (e.g., Mn, Co, Ni, Cd) as acid/base indicators,… read more here.
Keywords: living rat; online profiling; brain extracellular; rat brain ... See more keywords
Toward dynamic, anisotropic, high-resolution, and functional measurement in the brain extracellular space
Sign Up to like & getrecommendations! Published in 2022 at "Neurophotonics"
DOI: 10.1117/1.nph.9.3.032210
Abstract: Abstract. Diffusion of substances in the brain extracellular space (ECS) is important for extrasynaptic communication, extracellular ionic homeostasis, drug delivery, and metabolic waste clearance. However, substance diffusion is largely constrained by the geometry of brain… read more here.
Keywords: diffusion; measurement brain; brain; brain extracellular ... See more keywords
Identification of variable lymphocyte receptors that can target therapeutics to pathologically exposed brain extracellular matrix
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aau4245
Abstract: This study demonstrates targeting of blood-brain barrier disruption to deliver payloads at sites of neurological disease. Diseases that lead to blood-brain barrier (BBB) disruption will pathologically expose normally inaccessible brain extracellular matrix (ECM) to circulating… read more here.
Keywords: brain ecm; extracellular matrix; brain extracellular; variable lymphocyte ... See more keywords