Gray Matter Volume Loss in Proposed Brain‐First and Body‐First Parkinson's Disease Subtypes
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.29172
Abstract: α‐Synuclein pathology is associated with neuronal degeneration in Parkinson's disease (PD) and considered to sequentially spread across the brain (Braak stages). According to a new hypothesis of distinct α‐synuclein spreading directions based on the initial… read more here.
Keywords: brain first; parkinson disease; brain; pathology ... See more keywords
Cortical Functional Connectivity Changes in the Body‐First and Brain‐First Subtypes of Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2024 at "Movement Disorders"
DOI: 10.1002/mds.30071
Abstract: Rapid eye movement (REM) sleep behavior disorder (RBD) may precede motor symptoms in Parkinson's disease (PD) by years. According to a recent hypothesis, premotor RBD (pRBD) is a marker of the PD body‐first subtype, where… read more here.
Keywords: brain first; brain; body first; parkinson disease ... See more keywords
Clinical progression and genetic pathways in body-first and brain-first Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-025-00866-5
Abstract: Parkinson’s disease (PD) is a highly heterogeneous disorder with distinct phenotypes that can develop well before motor symptoms appear. Recently, two main phenotypes based on the different pathological spreading patterns of PD have been proposed:… read more here.
Keywords: progression; brain first; pathology; body first ... See more keywords
Save the Brain First: CTA and Mechanical Thrombectomy in Patients at Risk for Contrast-Induced Nephropathy
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Neuroradiology"
DOI: 10.3174/ajnr.a6515
Abstract: Stroke is one of the most common diseases affecting 800,000 Americans each year. It ranks fourth among all-cause mortality in the United States.[1][1] When patients present with stroke-like symptoms, the current American Heart Association/American Stroke… read more here.
Keywords: brain first; save brain; first cta; thrombectomy patients ... See more keywords
Exosomes in the Diseased Brain: First Insights from In vivo Studies
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2017.00142
Abstract: Extracellular vesicles (EVs) are nanoscale size vesicles secreted by cells and are important mediators of intercellular communication and genetic exchange. Exosomes, EVs generated in endosomal multivesicular bodies, have been the focus of numerous publications as… read more here.
Keywords: insights vivo; exosomes diseased; brain first; diseased brain ... See more keywords