Inadequate brain glycogen or sleep increases spreading depression susceptibility
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Neurology"
DOI: 10.1002/ana.25122
Abstract: Glycogen in astrocyte processes contributes to maintenance of low extracellular glutamate and K+ concentrations around excitatory synapses. Sleep deprivation (SD), a common migraine trigger, induces transcriptional changes in astrocytes, reducing glycogen breakdown. We hypothesize that… read more here.
Keywords: brain glycogen; sleep increases; glycogen sleep; glycogen ... See more keywords
Brain glycogen content is increased in the acute and interictal chronic stages of the mouse pilocarpine model of epilepsy.
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DOI: 10.1002/epi4.12599
Abstract: Glucose is the main brain fuel in fed conditions, while astrocytic glycogen is used as supplemental fuel when the brain is stimulated. Brain glycogen levels are decreased after induced seizures in rodents, but little is… read more here.
Keywords: epilepsy; glycogen levels; model; glycogen ... See more keywords