Chronic brain histamine depletion in adult mice induced depression-like behaviours and impaired sleep-wake cycle
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108179
Abstract: Histamine acts as a neurotransmitter to regulate various physiological processes. Brain histamine is synthesized from an essential amino acid histidine in a reaction catalysed by histidine decarboxylase (Hdc). Hdc-positive neurons exist mainly in the tuberomammillary… read more here.
Keywords: brain histamine; histamine depletion; histamine; mice ... See more keywords
Histaminergic neurons in the tuberomammillary nucleus as a control centre for wakefulness
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DOI: 10.1111/bph.15220
Abstract: Histamine plays pleiotropic roles as a neurotransmitter in the physiology of brain function, this includes the maintenance of wakefulness, appetite regulation and memory retrieval. Since numerous studies have revealed an association between histaminergic dysfunction and… read more here.
Keywords: brain histamine; wakefulness; histaminergic neurons; control ... See more keywords
An In Vivo Definition of Brain Histamine Dynamics Reveals Critical Neuromodulatory Roles for This Elusive Messenger
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314862
Abstract: Histamine is well known for mediating peripheral inflammation; however, this amine is also found in high concentrations in the brain where its roles are much less known. In vivo chemical dynamics are difficult to measure,… read more here.
Keywords: vivo definition; brain; brain histamine; histamine dynamics ... See more keywords