Brain insulin signaling, Alzheimer's disease pathology, and cognitive function.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of neurology"
DOI: 10.1002/ana.25826
Abstract: OBJECTIVE To examine associations of molecular markers of brain insulin signaling with Alzheimer's disease (AD) and cognition, among older persons with or without diabetes. METHODS This clinical-pathologic study was derived from a community-based cohort study,… read more here.
Keywords: brain insulin; pathology; cognitive function; brain ... See more keywords
Origins of Brain Insulin and Its Function.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-3540-2_1
Abstract: The brain or central nervous system (CNS) utilizes a vast amount of energy to sustain its basic functions, and most of the energy in the brain is derived from glucose. Whole-body energy and glucose homeostasis… read more here.
Keywords: insulin; brain insulin; insulin function; energy ... See more keywords
Brain insulin resistance: A treatment target for cognitive impairment and anhedonia in depression
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2019.01.016
Abstract: &NA; Type 2 Diabetes Mellitus (T2DM) and Major Depressive Disorder (MDD) are leading causes of disability worldwide. Indeed, both are costly and burdensome diseases at both individual and socio‐economic levels. Notably, there are similar pathophysiological… read more here.
Keywords: insulin; anhedonia; brain insulin; insulin resistance ... See more keywords
The brain as an insulin-sensitive metabolic organ
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101234
Abstract: Background The brain was once thought of as an insulin-insensitive organ. We now know that the insulin receptor is present throughout the brain and serves important functions in whole-body metabolism and brain function. Brain insulin… read more here.
Keywords: insulin sensitive; insulin; brain insulin; insulin resistance ... See more keywords
Reduced brain insulin signaling: A seminal process in Alzheimer's disease pathogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.09.016
Abstract: The synaptic dysfunction and death of neurons that mediate memory and cognition account together for the behavioral symptoms of Alzheimer's disease (AD). Reduced insulin signaling in the brain is a hallmark of AD patients, even… read more here.
Keywords: insulin; brain insulin; alzheimer disease; brain ... See more keywords
Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.01.044
Abstract: ABSTRACT Alzheimer's disease (AD) constitutes a major socioeconomic challenge due to its disabling features and the rise in prevalence (especially among (peri)menopausal women and type 2 diabetes patients). The precise etiopathogenesis of AD remains poorly… read more here.
Keywords: insulin signalling; insulin; brain insulin; metabolism ... See more keywords
Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/s41380-018-0086-5
Abstract: Obesity and diabetes in humans are associated with increased rates of anxiety and depression. To understand the role of the gut microbiome and brain insulin resistance in these disorders, we evaluated behaviors and insulin action… read more here.
Keywords: insulin; brain insulin; anxiety depression; gut microbiota ... See more keywords
Brain insulin resistance and cognitive function: influence of exercise.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00375.2022
Abstract: Exercise has systemic health benefits in people, in part, through improving whole-body insulin sensitivity. The brain is an insulin sensitive organ that is often underdiscussed relative to skeletal muscle, liver, and adipose tissue. While brain… read more here.
Keywords: function; insulin resistance; brain; brain insulin ... See more keywords
Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.161498
Abstract: BACKGROUND Insulin resistance of the brain can unfavorably affect long-term weight maintenance and body fat distribution. Little is known if and how brain insulin sensitivity can be restored in humans. We aimed to evaluate the… read more here.
Keywords: brain; insulin sensitivity; brain insulin; exercise ... See more keywords
150-OR: Brain Insulin Sensitivity Is Modulated by Menstrual Cycle
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.2337/db20-150-or
Abstract: Insulin action in the human brain modulates whole-body metabolism by increasing peripheral insulin sensitivity and suppressing endogenous glucose production. In brain insulin resistance, this modulatory function of the brain is impaired. Experimental evidence from rodents… read more here.
Keywords: insulin; brain insulin; menstrual cycle; none ... See more keywords
Empagliflozin Improves Insulin Sensitivity of the Hypothalamus in Humans With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial.
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes care"
DOI: 10.2337/dc21-1136
Abstract: OBJECTIVE Insulin action in the human brain reduces food intake, improves whole-body insulin sensitivity, and modulates body fat mass and its distribution. Obesity and type 2 diabetes are often associated with brain insulin resistance, resulting… read more here.
Keywords: insulin; brain insulin; insulin resistance; brain ... See more keywords