Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2021.1907575
Abstract: Abstract Ischaemic stroke is a leading cause of death and disability. One of the major pathogenic mechanisms after ischaemia includes the switch to the glycolytic pathway, leading to tissue acidification. Carbonic anhydrase (CA) contributes to… read more here.
Keywords: brain ischaemia; carbonic anhydrase; ischaemia; vivo ... See more keywords
A cortical microvascular structure in vascular dementia, Alzheimer's disease, frontotemporal lobar degeneration and nondemented controls: a sign of angiogenesis due to brain ischaemia?
Sign Up to like & getrecommendations! Published in 2019 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12552
Abstract: We observed a microvascular structure in the cerebral cortex that has not, to our knowledge, been previously described. We have termed the structure a ‘raspberry’, referring to its appearance under a bright‐field microscope. We hypothesized… read more here.
Keywords: angiogenesis due; microvascular structure; vascular dementia; brain ischaemia ... See more keywords
Recurrent brain ischaemia and deep vein thrombosis: the clot thickens
Sign Up to like & getrecommendations! Published in 2017 at "Practical Neurology"
DOI: 10.1136/practneurol-2016-001581
Abstract: A 65-year-old man presented with two transient ischaemic attacks, and was then found to have a deep vein thrombosis. He later had recurrent ischaemic strokes. After thorough investigation, the only cause we identified was a… read more here.
Keywords: deep vein; ischaemia deep; vein thrombosis; brain ischaemia ... See more keywords