Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome.
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DOI: 10.1111/imm.70070
Abstract: Down syndrome (DS) is characterised by delayed brain development and intellectual disabilities. Brain macrophages originate from primitive macrophages that arise from mesodermal cells in the yolk sac and play a role in brain development. Previously,… read more here.
Keywords: differentiation; brain; brain macrophages; stem cells ... See more keywords
Brain macrophages and pial fibroblasts promote inflammation in a hypomyelination model
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DOI: 10.1186/s40478-025-02063-3
Abstract: Many neurological diseases remain difficult to treat, necessitating further elucidation of their pathogenesis. Conditional inactivation of Pdgfra in Nestin-expressing cells leads to the depletion of platelet-derived growth factor receptor-alpha+ (PDGFRα+) oligodendroglial lineage cells responsible for… read more here.
Keywords: brain macrophages; pial fibroblasts; hypomyelination; inflammation ... See more keywords