Association of Twice-Daily Radiotherapy With Subsequent Brain Metastases in Adults With Small Cell Lung Cancer
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DOI: 10.1001/jamanetworkopen.2019.0103
Abstract: Importance Although thoracic twice-daily radiotherapy (TDRT) is one of the standards of care for small cell lung cancer, its association with brain metastases remains unknown. Objective To investigate the association of TDRT vs once-daily radiotherapy… read more here.
Keywords: brain metastases; group; cell lung; lung cancer ... See more keywords
Analysis of Rates of Brain Metastases and Association With Breast Cancer Subtypes in Ontario, Canada
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DOI: 10.1001/jamanetworkopen.2022.25424
Abstract: This cohort study describes clinical cumulative incidence of brain metastases among patients with de novo metastatic breast cancer using population health administrative databases in Ontario, Canada. read more here.
Keywords: breast cancer; brain metastases; ontario canada;
Association of Brain Metastases With Survival in Patients With Limited or Stable Extracranial Disease
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DOI: 10.1001/jamanetworkopen.2023.0475
Abstract: Key Points Question What are the clinical outcomes of patients with intracranial metastatic disease in the setting of stable extracranial disease (IMD-SE) compared with patients with brain metastases and progressive extracranial disease (IMD-PE)? Findings This… read more here.
Keywords: patients imd; brain metastases; stable extracranial; disease ... See more keywords
Intracranial and Extracranial Progression and Their Correlation With Overall Survival After Stereotactic Radiosurgery in a Multi-institutional Cohort With Brain Metastases
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DOI: 10.1001/jamanetworkopen.2023.10117
Abstract: Key Points Question For patients completing stereotactic radiosurgery (SRS) for brain metastases, are intracranial and extracranial progression reliable surrogates for overall survival (OS)? Findings In this cohort study of 1383 patients undergoing an initial course… read more here.
Keywords: extracranial progression; stereotactic radiosurgery; brain metastases; intracranial extracranial ... See more keywords
Targeted Therapy as an Alternative to Whole-Brain Radiotherapy in EGFR-Mutant or ALK-Positive Non-Small-Cell Lung Cancer With Brain Metastases.
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DOI: 10.1001/jamaoncol.2017.1047
Abstract: Clinical Question Is up-front whole-brain radiotherapy required to treat multiple brain metastases from non-small-cell lung cancer when highly active targeted therapies are available? Clinical Application Patients with EGFR-mutant or ALK-positive non-small-cell lung cancer with brain… read more here.
Keywords: brain metastases; brain radiotherapy; non small; brain ... See more keywords
Immunotherapy and Symptomatic Radiation Necrosis in Patients With Brain Metastases Treated With Stereotactic Radiation
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DOI: 10.1001/jamaoncol.2017.3993
Abstract: This study investigates the association between immunotherapy and symptomatic radiation necrosis in patients with melanoma, non–small-cell lung cancer, or renal cell carcinoma and newly diagnosed brain metastases treated with stereotactic radiation therapy. read more here.
Keywords: necrosis patients; brain metastases; immunotherapy symptomatic; symptomatic radiation ... See more keywords
Tucatinib vs Placebo, Both in Combination With Trastuzumab and Capecitabine, for Previously Treated ERBB2 (HER2)-Positive Metastatic Breast Cancer in Patients With Brain Metastases
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DOI: 10.1001/jamaoncol.2022.5610
Abstract: Key Points Question Can tucatinib, trastuzumab, and capecitabine provide systemic and intracranial benefit for patients with ERBB2 (HER2)-positive metastatic breast cancer and brain metastases? Findings In this exploratory subgroup analysis of a randomized clinical trial… read more here.
Keywords: trastuzumab capecitabine; breast cancer; brain metastases; brain ... See more keywords
Dosimetric quality and delivery efficiency of robotic radiosurgery for brain metastases: Comparison with C‐arm linear accelerator based plans
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DOI: 10.1002/acm2.12746
Abstract: Abstract The incidence of brain metastases is increasing and various treatment modalities exist for brain metastases. The aim of this study was to investigate the dosimetric quality and delivery efficiency of robotic radiosurgery (CyberKnife) for… read more here.
Keywords: brain metastases; based plans; linac based; arm linac ... See more keywords
Dosimetric potential of knowledge‐based planning model trained with HyperArc plans for brain metastases
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DOI: 10.1002/acm2.13836
Abstract: Abstract Objective Dosimetric potential of knowledge‐based RapidPlan planning model trained with HyperArc plans (Model‐HA) for brain metastases has not been reported. We developed a Model‐HA and compared its performance with that of clinical volumetric modulated… read more here.
Keywords: brain metastases; brain; plans brain; model ... See more keywords
The growing importance of lesion volume as a prognostic factor in patients with multiple brain metastases treated with stereotactic radiosurgery
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DOI: 10.1002/cam4.1352
Abstract: Stereotactic Radiosurgery (SRS) is considered standard of care for patients with 1–3 brain metastases (BM). Recent observational studies have shown equivalent OS in patients with 5+ BM compared to those with 2–4, suggesting SRS alone… read more here.
Keywords: brain metastases; stereotactic radiosurgery; volume; histology ... See more keywords
Applicability of the adjusted graded prognostic assessment for lung cancer with brain metastases using molecular markers (Lung‐molGPA) in a Chinese cohort: A retrospective study of multiple institutions
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DOI: 10.1002/cam4.3485
Abstract: In this era of precision medicine, prognostic heterogeneity is an important feature of patients with non‐small cell lung cancer (NSCLC) with brain metastases (BM). This multi‐institutional study is aimed to verify the applicability of the… read more here.
Keywords: brain metastases; medicine; applicability adjusted; lung cancer ... See more keywords