Cytotoxicity profile of pristine graphene on brain microvascular endothelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3786
Abstract: Graphene‐based nanomaterials hold the potential to be used in a wide variety of applications, including biomedical devices. Pristine graphene (PG) is an un‐functionalized, defect‐free type of graphene that could be used as a material for… read more here.
Keywords: brain microvascular; pristine graphene; microvascular endothelial; endothelial cells ... See more keywords
Oxygen gradients dictate angiogenesis but not barriergenesis in a 3D brain microvascular model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30840
Abstract: A variety of biophysical properties are known to regulate angiogenic sprouting, and in vitro systems can parse the individual effects of these factors in a controlled setting. Here, a three‐dimensional brain microvascular model interrogates how… read more here.
Keywords: brain microvascular; brain; oxygen; microvascular model ... See more keywords
Piperine Decreases Binding of Drugs to Human Plasma and Increases Uptake by Brain Microvascular Endothelial Cells
Sign Up to like & getrecommendations! Published in 2017 at "Phytotherapy Research"
DOI: 10.1002/ptr.5929
Abstract: We previously reported that piperine, an active alkaloidal principal of black and long peppers, enhances drug bioavailability by inhibiting drug metabolism. Another mechanism influencing drug availability/uptake is its free fraction. Since piperine is highly lipophilic,… read more here.
Keywords: human plasma; brain microvascular; drug; piperine ... See more keywords
Isolation and Culture of Brain Microvascular Endothelial Cells for In Vitro Blood-Brain Barrier Studies.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7571-6_23
Abstract: The blood-brain barrier (BBB) is essential to maintain the proper microenvironment for brain function. Although formed by different cell types, the endothelial cells (ECs) of the brain microvessels provide the BBB with its selective permeability.… read more here.
Keywords: blood brain; brain microvascular; microvascular endothelial; endothelial cells ... See more keywords
Regulation of Human Brain Microvascular Endothelial Cell Adhesion and Barrier Functions by Memantine
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-0917-x
Abstract: Vascular risk factors have been linked to cognitive decline and dementia in the elderly. Microvascular inflammation, especially of the endothelium, may contribute to the progression of neurodegenerative events in Alzheimer’s disease (AD). Memantine, an uncompetitive… read more here.
Keywords: cell adhesion; brain microvascular; microvascular endothelial; human brain ... See more keywords
The Protective Effects of Ramelteon Against Isoflurane-Induced Insults and Inflammatory Response in Brain Microvascular Endothelial Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicity research"
DOI: 10.1007/s12640-020-00309-7
Abstract: Anesthetic-induced cognitive impairment has been observed clinically. The mechanism underlying anesthetic-induced cognitive impairment is closely associated with neuronal apoptosis and neuroinflammation. Ramelteon is a potent and highly selective melatonin receptor agonist that has been used… read more here.
Keywords: brain microvascular; isoflurane induced; microvascular endothelial; endothelial cells ... See more keywords
Zika virus NS1 affects the junctional integrity of human brain microvascular endothelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochimie"
DOI: 10.1016/j.biochi.2020.06.011
Abstract: Zika virus (ZIKV) infection leads to microcephaly in newborns. Flaviviruses are known to secrete NS1 protein extracellularly and its concentration in serum directly co-relate to disease severity. The presence of ZIKV-NS1 near the brain microvascular… read more here.
Keywords: brain microvascular; microvascular endothelial; zika virus; brain ... See more keywords
NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain microvascular endothelial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102454
Abstract: The excitatory neurotransmitter glutamate gates post-synaptic N-methyl-d-aspartate (NMDA) receptors (NMDARs) to mediate extracellular Ca2+ entry and stimulate neuronal nitric oxide (NO) synthase to release NO and trigger neurovascular coupling (NVC). Neuronal and glial NMDARs may… read more here.
Keywords: brain microvascular; flux independent; ca2; nmda receptors ... See more keywords
Effects of Platelet-Activating Factor on Brain Microvascular Endothelial Cells
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.02.039
Abstract: Platelet-activating factor (PAF) is a potent phospholipid mediator that exerts various pathophysiological effects by interacting with a G protein-coupled receptor. PAF has been reported to increase the permeability of the blood-brain barrier (BBB) via incompletely… read more here.
Keywords: platelet activating; activating factor; brain microvascular; paf ... See more keywords
Oxytocin inhibits ox‐LDL‐induced adhesion of monocytic THP‐1 cells to human brain microvascular endothelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.10.022
Abstract: &NA; The attachment of monocytes to human brain microvascular endothelial cells (HBMVEs) caused by oxidized low‐density lipoprotein (ox‐LDL) is associated with an early event and the pathological progression of cerebrovascular diseases. Oxytocin (OT) is a… read more here.
Keywords: thp; brain microvascular; ldl; human brain ... See more keywords
Identification of the proteins of Borrelia garinii interacting with human brain microvascular endothelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "Ticks and tick-borne diseases"
DOI: 10.1016/j.ttbdis.2020.101451
Abstract: Lyme borreliosis is one of the major tick-borne diseases in Europe. Events of the translocation of Borrelia across the blood-brain barrier (BBB) involve multiple interactions between borrelial surface proteins and receptors on the brain microvascular… read more here.
Keywords: proteins borrelia; brain microvascular; microvascular endothelial; endothelial cells ... See more keywords