Stretchable Mesh Nanoelectronics for 3D Single‐Cell Chronic Electrophysiology from Developing Brain Organoids
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202106829
Abstract: Human induced pluripotent stem cell derived brain organoids have shown great potential for studies of human brain development and neurological disorders. However, quantifying the evolution of the electrical properties of brain organoids during development is… read more here.
Keywords: development; developing brain; brain organoids; cell ... See more keywords
Brain organoids: Human 3D models to investigate neuronal circuits assembly, function and dysfunction
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2020.147028
Abstract: The human brain is characterized by an extraordinary complexity of neuronal and nonneuronal cell types, wired together into patterned neuronal circuits, which represent the anatomical substrates for the execution of high-order cognitive functions. Brain circuits'… read more here.
Keywords: organoid protocols; human brain; brain organoids; brain organoid ... See more keywords
Recent Advances in Brain Organoid Technology for Human Brain Research.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c17467
Abstract: Brain organoids are self-assembled three-dimensional aggregates with brain-like cell types and structures and have emerged as new model systems that can be used to investigate human neurodevelopment and neurological disorders. However, brain organoids are not… read more here.
Keywords: advances brain; brain; organoid technology; brain organoids ... See more keywords
Three-dimensional modeling of human neurodegeneration: brain organoids coming of age
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Psychiatry"
DOI: 10.1038/s41380-019-0500-7
Abstract: The prevalence of dementia and other neurodegenerative diseases is rapidly increasing in aging nations. These relentless and progressive diseases remain largely without disease-modifying treatments despite decades of research and investments. It is becoming clear that… read more here.
Keywords: three dimensional; disease; neurodegeneration; brain organoids ... See more keywords
Brain organoid-on-a-chip: A next-generation human brain avatar for recapitulating human brain physiology and pathology.
Sign Up to like & getrecommendations! Published in 2022 at "Biomicrofluidics"
DOI: 10.1063/5.0121476
Abstract: Neurodegenerative diseases and neurodevelopmental disorders have become increasingly prevalent; however, the development of new pharmaceuticals to treat these diseases has lagged. Animal models have been extensively utilized to identify underlying mechanisms and to validate drug… read more here.
Keywords: brain; pathology; physiology; human brain ... See more keywords
Mapping the Ethical Issues of Brain Organoid Research and Application.
Sign Up to like & getrecommendations! Published in 2021 at "AJOB neuroscience"
DOI: 10.1080/21507740.2021.1896603
Abstract: In 2008, researchers created human three-dimensional neural tissue - known as the pioneering work of "brain organoids." In recent years, some researchers have transplanted human brain organoids into animal brains for applicational purposes. With these… read more here.
Keywords: research; research application; organoid research; brain organoid ... See more keywords
Public Engagement With Brain Organoid Research and Application: Lessons From Genome Editing
Sign Up to like & getrecommendations! Published in 2022 at "AJOB Neuroscience"
DOI: 10.1080/21507740.2022.2048733
Abstract: Sawai and colleagues (2022) provide an excellent overview of the ethical issues of brain organoid research and application. They point out that regulation for these kinds of endeavors is urgently needed and provide suggestions for… read more here.
Keywords: genome editing; organoid research; brain; public engagement ... See more keywords
What Brain Organoid Research Can Gain From Engaging Biospecimen Donors
Sign Up to like & getrecommendations! Published in 2022 at "AJOB Neuroscience"
DOI: 10.1080/21507740.2022.2048734
Abstract: Sawai and colleagues (2022) have continued the effort begun by other scholars to articulate the current and future ethical challenges of brain organoid research. They take a step beyond some prior reviews by summarizing ethically-relevant… read more here.
Keywords: organoid research; brain; biospecimen donors; brain organoids ... See more keywords
Benchmarking brain organoid recapitulation of fetal corticogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Translational Psychiatry"
DOI: 10.1101/2022.04.22.488753
Abstract: Brain organoids are becoming increasingly relevant to dissect the molecular mechanisms underlying psychiatric and neurological conditions. The in vitro recapitulation of key features of human brain development affords the unique opportunity of investigating the developmental… read more here.
Keywords: fetal corticogenesis; brain; corticogenesis; recapitulation ... See more keywords
NEUBOrg: Artificially Induced Pluripotent Stem Cell-Derived Brain Organoid to Model and Study Genetics of Alzheimer’s Disease Progression
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.643889
Abstract: Alzheimer’s disease (AD) is the most common type of neurodegenerative diseases. There are over 44 million people living with the disease worldwide. While there are currently no effective treatments for AD, induced pluripotent stem cell-derived… read more here.
Keywords: alzheimer disease; genetics; brain organoid; progression ... See more keywords
Artificially Induced Pluripotent Stem Cell-Derived Whole-Brain Organoid for Modelling the Pathophysiology of Metachromatic Leukodystrophy and Drug Repurposing
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9040440
Abstract: Metachromatic leukodystrophy (MLD) is a rare neurodegenerative disease that results from a deficiency of the lysosomal enzyme arylsulfatase A (ARSA). Worldwide, there are between one in 40,000 and one in 160,000 people living with the… read more here.
Keywords: metachromatic leukodystrophy; artificially induced; brain organoid; induced pluripotent ... See more keywords