Stretchable Mesh Nanoelectronics for 3D Single‐Cell Chronic Electrophysiology from Developing Brain Organoids
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202106829
Abstract: Human induced pluripotent stem cell derived brain organoids have shown great potential for studies of human brain development and neurological disorders. However, quantifying the evolution of the electrical properties of brain organoids during development is… read more here.
Keywords: development; developing brain; brain organoids; cell ... See more keywords
Stem cell‐based region‐specific brain organoids: Novel models to understand neurodevelopmental defects
Sign Up to like & getrecommendations! Published in 2022 at "Birth Defects Research"
DOI: 10.1002/bdr2.2004
Abstract: The study of human brain development and neurodevelopmental defects has remained challenging so far due to unique, specific, and complex underlying processes. Recent advances in the technologies and protocols of in vitro human brain organoid… read more here.
Keywords: stem cell; development; brain; human brain ... See more keywords
Brain organoids: Human 3D models to investigate neuronal circuits assembly, function and dysfunction
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2020.147028
Abstract: The human brain is characterized by an extraordinary complexity of neuronal and nonneuronal cell types, wired together into patterned neuronal circuits, which represent the anatomical substrates for the execution of high-order cognitive functions. Brain circuits'… read more here.
Keywords: organoid protocols; human brain; brain organoids; brain organoid ... See more keywords
Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.038
Abstract: SUMMARY Human brain organoid systems offer unprecedented opportunities to investigate both neurodevelopmental and neurological disease. Single-cell-based transcriptomics or epigenomics have dissected the cellular and molecular heterogeneity in the brain organoids, revealing a complex organization. Similar… read more here.
Keywords: single cell; fetal brain; cell transcriptomes; brain organoids ... See more keywords
Patterning of brain organoids derived from human pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2022.102536
Abstract: The emerging technology of brain organoids deriving from human pluripotent stem cells provides unprecedented opportunities to study human brain development and associated disorders. Various brain organoid protocols have been developed that can recapitulate some key… read more here.
Keywords: pluripotent stem; brain organoids; stem cells; human pluripotent ... See more keywords
Three-dimensional in vitro tissue culture models of brain organoids
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2021.113619
Abstract: Brain organoids are three-dimensional self-assembled structures that are derived from human induced pluripotent stem cells (hiPSCs). They can recapitulate the spatiotemporal organization and function of the brain, presenting a robust system for in vitro modeling… read more here.
Keywords: three dimensional; organoids three; brain organoids; culture models ... See more keywords
Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2016.12.005
Abstract: The recent Zika virus (ZIKV) epidemic is associated with microcephaly in newborns. Although the connection between ZIKV and neurodevelopmental defects is widely recognized, the underlying mechanisms are poorly understood. Here we show that two recently… read more here.
Keywords: premature differentiation; recent zika; brain organoids; differentiation neural ... See more keywords
Crinkle-Cut Brain Organoids.
Sign Up to like & getrecommendations! Published in 2018 at "Cell stem cell"
DOI: 10.1016/j.stem.2018.04.011
Abstract: In large mammalian brains, including those of humans, the surface of the cortex is highly folded. How these convolutions form is still unclear, but recent work in Nature Physics by Karzbrun et al. (2018) supports a… read more here.
Keywords: brain organoids; crinkle cut; cut brain;
Brain Organoids to Study SARS-Cov-2 Infection of Developing CNS
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology Letters"
DOI: 10.1016/s0378-4274(21)00409-4
Abstract: Early reports from Wuhan suggested that 36% of COVID-19 patients show neurological symptoms, later European studies showed as much as 60%;cases of viral encephalitis have been reported. This suggests that the virus might be neurotropic… read more here.
Keywords: organoids study; infection; brain organoids; virus ... See more keywords
Recent Advances in Brain Organoid Technology for Human Brain Research.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c17467
Abstract: Brain organoids are self-assembled three-dimensional aggregates with brain-like cell types and structures and have emerged as new model systems that can be used to investigate human neurodevelopment and neurological disorders. However, brain organoids are not… read more here.
Keywords: advances brain; brain; organoid technology; brain organoids ... See more keywords
Three-dimensional modeling of human neurodegeneration: brain organoids coming of age
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Psychiatry"
DOI: 10.1038/s41380-019-0500-7
Abstract: The prevalence of dementia and other neurodegenerative diseases is rapidly increasing in aging nations. These relentless and progressive diseases remain largely without disease-modifying treatments despite decades of research and investments. It is becoming clear that… read more here.
Keywords: three dimensional; disease; neurodegeneration; brain organoids ... See more keywords