Brain‐Penetrating and Disease Site‐Targeting Manganese Dioxide‐Polymer‐Lipid Hybrid Nanoparticles Remodel Microenvironment of Alzheimer's Disease by Regulating Multiple Pathological Pathways
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202207238
Abstract: Finding effective disease‐modifying treatment for Alzheimer's disease remains challenging due to an array of factors contributing to the loss of neural function. The current study demonstrates a new strategy, using multitargeted bioactive nanoparticles to modify… read more here.
Keywords: brain penetrating; disease; alzheimer disease; brain ... See more keywords
Design and synthesis of benzodiazepines as brain penetrating PARP-1 inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2053524
Abstract: Abstract The poly (ADP-ribose) polymerase (PARP) inhibitors play a crucial role in cancer therapy. However, most approved PARP inhibitors cannot cross the blood-brain barrier, thus limiting their application in the central nervous system. Here, 55… read more here.
Keywords: brain; inhibition; brain penetrating; penetrating parp ... See more keywords
Identification and in vivo characterization of a brain-penetrating nanobody
Sign Up to like & getrecommendations! Published in 2020 at "Fluids and Barriers of the CNS"
DOI: 10.1186/s12987-020-00226-z
Abstract: Background Preclinical models to determine blood to brain transport ability of therapeutics are often ambiguous. In this study a method is developed that relies on CNS target-engagement and is able to rank brain-penetrating capacities. This… read more here.
Keywords: transferrin receptor; receptor; brain; brain penetrating ... See more keywords