Predicting the Brain-To-Plasma Unbound Partition Coefficient of Compounds via Formula-Guided Network
Sign Up to like & getrecommendations! Published in 2025 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.5c00590
Abstract: Blood-brain barrier (BBB) permeability plays a crucial role in determining drug efficacy in the brain, with the brain-to-plasma unbound partition coefficient (Kp,uu) recognized as a key parameter of BBB permeability in drug development. However, Kp,uu… read more here.
Keywords: unbound partition; brain plasma; partition coefficient; brain ... See more keywords
Transferrin-Conjugated Chitosan Nanoparticles for Direct Nose-to-Brain Delivery of Ziprasidone: Pharmacokinetic and Pharmacodynamic Evaluation.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.5c00863
Abstract: Ziprasidone (ZS) exhibits limited central nervous system (CNS) penetration due to the blood-brain barrier (BBB). This study investigated the pharmacokinetics and pharmacodynamics of ZS-loaded nanoparticles (NP) and transferrin-functionalized nanoparticles (Tf-NP) administered intravenously (IV) and intranasally… read more here.
Keywords: brain plasma; transferrin conjugated; brain; conjugated chitosan ... See more keywords
Efficient brain uptake of piperine and its pharmacokinetics characterization after oral administration
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DOI: 10.1080/00498254.2017.1405293
Abstract: Abstract 1. Piperine, the major biological active component in black pepper has been associated with miscellaneous pharmacological effects, especially on central nervous system. To correlate with its neurological activity, a comprehensive pharmacokinetic profile of piperine… read more here.
Keywords: efficient brain; piperine; brain; oral administration ... See more keywords