Targeted Therapy as an Alternative to Whole-Brain Radiotherapy in EGFR-Mutant or ALK-Positive Non-Small-Cell Lung Cancer With Brain Metastases.
Sign Up to like & getrecommendations! Published in 2017 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2017.1047
Abstract: Clinical Question Is up-front whole-brain radiotherapy required to treat multiple brain metastases from non-small-cell lung cancer when highly active targeted therapies are available? Clinical Application Patients with EGFR-mutant or ALK-positive non-small-cell lung cancer with brain… read more here.
Keywords: brain metastases; brain radiotherapy; non small; brain ... See more keywords
Dosimetric analysis of SIB whole brain radiotherapy planning: Comparison of coplanar VMAT and tomotherapy techniques
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.70313
Abstract: Abstract Background Radiotherapy techniques have advanced significantly over the past few decades. Whole‐brain radiotherapy combined with a simultaneous integrated boost (WBRT+SIB) is increasingly used to treat limited brain metastases. Purpose To retrospectively compare helical tomotherapy… read more here.
Keywords: brain; vmat; whole brain; tomotherapy ... See more keywords
Brain metastases of lung cancer: comparison of survival outcomes among whole brain radiotherapy, whole brain radiotherapy with consecutive boost, and simultaneous integrated boost
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-020-03359-8
Abstract: Purpose Radiotherapy is the mainstay for treating brain metastasis (BM). The objective of this study is to evaluate the overall survival (OS) of patients with BM of lung cancer treated with different radiotherapy modalities. Methods… read more here.
Keywords: boost; radiotherapy; brain radiotherapy; cancer ... See more keywords
Whole brain radiotherapy for non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2017 at "The Lancet"
DOI: 10.1016/s0140-6736(17)30895-4
Abstract: 1394 www.thelancet.com Vol 389 April 8, 2017 brain radiotherapy (WBRT) versus optimal supportive care in patients with non-small cell lung cancer (NSCLC) and brain metastases. We commend the authors on undertaking this important study. This… read more here.
Keywords: brain radiotherapy; radiotherapy; non small; wbrt ... See more keywords
Lymphopenia associated with whole-brain radiotherapy and its effects on clinical outcomes of patients with brain metastases
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DOI: 10.1038/s41598-024-71943-w
Abstract: There is increasing awareness of radiotherapy’s potential side effects, such as lymphopenia. Therefore, this study aimed to establish the association between WBRT and the development of lymphopenia in patients with brain metastases undergoing brain radiotherapy… read more here.
Keywords: brain; brain metastases; radiotherapy; post ... See more keywords
Randomized phase III study of high-dose methotrexate and whole-brain radiotherapy with/without temozolomide for newly diagnosed primary CNS lymphoma: JCOG1114C
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noac246
Abstract: Abstract Background The goal was to determine whether the addition of temozolomide (TMZ) to the standard treatment of high-dose methotrexate (HD-MTX) and whole-brain radiotherapy (WBRT) for primary central nervous system lymphoma (PCNSL) improves survival. Methods… read more here.
Keywords: brain radiotherapy; whole brain; dose methotrexate; newly diagnosed ... See more keywords
Stereotactic radiosurgery for 1–10 brain metastases to avoid whole-brain radiotherapy: Results of the CYBER-SPACE randomized phase 2 trial
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DOI: 10.1093/neuonc/noae201
Abstract: Abstract Background Stereotactic radiosurgery (SRS) is an emerging alternative to whole-brain radiotherapy (WBRT) for treating multiple brain metastases (BM), reducing toxicity, and improving tumor control. The CYBER-SPACE trial compared SRS based on either SPACE or… read more here.
Keywords: brain; brain metastases; space; whole brain ... See more keywords
Effectiveness of temozolomide combined with whole brain radiotherapy for non‐small cell lung cancer brain metastases
Sign Up to like & getrecommendations! Published in 2018 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.12795
Abstract: We performed a retrospective analysis to compare the efficacy of whole brain radiotherapy (WBRT) combined with temozolomide (TMZ) versus WBRT alone as first‐line treatment for brain metastases (BM). read more here.
Keywords: brain metastases; brain radiotherapy; cancer; brain ... See more keywords
Lymphocytopenia and survival after whole‐brain radiotherapy in patients with small‐cell lung cancer
Sign Up to like & getrecommendations! Published in 2023 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.14868
Abstract: To investigate whether whole‐brain radiotherapy (WBRT) decreases lymphocyte counts and evaluate the impact of treatment‐related lymphopenia on survival in patients with brain metastasis. read more here.
Keywords: brain radiotherapy; whole brain; brain; cancer lymphocytopenia ... See more keywords
Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy
Sign Up to like & getrecommendations! Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/2459608
Abstract: Introduction Hippocampi sparing whole brain radiotherapy (WBRT) is an evolving approach in the treatment of patients with multiple brain metastases, pursuing mitigation of verbal memory decline as a consequence of hippocampal radiation injury. Accumulating data… read more here.
Keywords: laterality; hippocampal avoiding; brain radiotherapy; brain ... See more keywords
Reduced-dose whole brain radiotherapy is an effective consolidation strategy for parenchymal-only secondary cns lymphoma
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DOI: 10.1182/blood-2025-7181
Abstract: Introduction: While optimal consolidation strategies for patients with secondary central nervous system lymphoma (SCNSL) remain debated, autologous stem cell transplant (ASCT) is commonly used in eligible patients. However, effective alternatives are needed for those who… read more here.
Keywords: brain; brain radiotherapy; consolidation; scnsl ... See more keywords