Brain-Resident T Cells Following Viral Infection.
Sign Up to like & getrecommendations! Published in 2019 at "Viral immunology"
DOI: 10.1089/vim.2018.0084
Abstract: Activated CD8+ lymphocytes infiltrate the brain in response to many viral infections; where some remain stationed long term as memory T cells. Brain-resident memory T cells (bTRM) are positioned to impart immediate defense against recurrent… read more here.
Keywords: cells following; brain resident; resident cells; following viral ... See more keywords
CD4 T cells control development and maintenance of brain-resident CD8 T cells during polyomavirus infection
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007365
Abstract: Tissue-resident memory CD8 T (TRM) cells defend against microbial reinfections at mucosal barriers; determinants driving durable TRM cell responses in non-mucosal tissues, which often harbor opportunistic persistent pathogens, are unknown. JC polyomavirus (JCPyV) is a… read more here.
Keywords: cd4 cells; cd8; brain resident; cd8 cells ... See more keywords
Crosstalk between peripheral and the brain-resident immune components in epilepsy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of integrative neuroscience"
DOI: 10.31083/j.jin2101009
Abstract: Epilepsy is one of the most common neurology diseases. It is characterized by recurrent, spontaneous seizures and accompanied by various comorbidities which can significantly affect a person's life. Accumulating evidence indicates an essential pathophysiological role… read more here.
Keywords: brain resident; resident immune; crosstalk; epilepsy ... See more keywords
IFN-γ production by brain-resident cells activates cerebral mRNA expression of a wide spectrum of molecules critical for both innate and T cell-mediated protective immunity to control reactivation of chronic infection with Toxoplasma gondii
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1110508
Abstract: We previously demonstrated that brain-resident cells produce IFN-γ in response to reactivation of cerebral infection with Toxoplasma gondii. To obtain an overall landscape view of the effects of IFN-γ from brain-resident cells on the cerebral… read more here.
Keywords: ifn production; resident cells; immunity; brain resident ... See more keywords
Brain-Resident Microglia and Blood-Borne Macrophages Orchestrate Central Nervous System Inflammation in Neurodegenerative Disorders and Brain Cancer
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DOI: 10.3389/fimmu.2018.00697
Abstract: Inflammation is a hallmark of different central nervous system (CNS) pathologies. It has been linked to neurodegenerative disorders as well as primary and metastatic brain tumors. Microglia, the brain-resident immune cells, are emerging as a… read more here.
Keywords: brain resident; blood borne; neurodegenerative disorders; inflammation ... See more keywords
Age-dependent effects of gut microbiota metabolites on brain resident macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.944526
Abstract: In recent years, development of age-related diseases, such as Alzheimer's and Parkinson's disease, as well as other brain disorders, including anxiety, depression, and schizophrenia have been shown to be associated with changes in the gut… read more here.
Keywords: age dependent; resident macrophages; brain; brain resident ... See more keywords