Unbiased Lipidomics and Metabolomics of Human Brain Samples.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7704-8_17
Abstract: Mass spectrometry (MS)-based lipidomics and metabolomics approaches have been used to discover new diagnostic and therapeutic targets of neurodegenerative disorders. Here, we describe a protocol to conduct an integrated metabolomics and lipidomics profiling of postmortem… read more here.
Keywords: unbiased lipidomics; brain samples; human brain; metabolomics human ... See more keywords
Comparison of Reference Genes for Transcriptional Studies in Postmortem Human Brain Tissue Under Different Conditions
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-018-0309-4
Abstract: Research on neurodegenerative diseases is a hot topic worldwide [1], and MRI, genetics and epigenetics, and animal models have been commonly used. Considering species differences, research on human brain samples is irreplaceable [2]. Many countries… read more here.
Keywords: reference genes; brain samples; tissue; human brain ... See more keywords
Assessment of Polychlorinated Biphenyls and Their Hydroxylated Metabolites in Postmortem Human Brain Samples: Age and Brain Region Differences
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Science & Technology"
DOI: 10.1021/acs.est.2c00581
Abstract: Exposure to polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) has been implicated in neurodevelopmental disorders. However, the distribution of PCBs and OH-PCBs in the human brain has not been characterized. This study investigated the… read more here.
Keywords: polychlorinated biphenyls; brain; human brain; brain samples ... See more keywords
Volumetric Characterization of Microvasculature in Ex Vivo Human Brain Samples By Serial Sectioning Optical Coherence Tomography
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Biomedical Engineering"
DOI: 10.1109/tbme.2022.3175072
Abstract: Objective: Serial sectioning optical coherence tomography (OCT) enables accurate volumetric reconstruction of several cubic centimeters of human brain samples. We aimed to identify anatomical features of the ex vivo human brain, such as intraparenchymal blood… read more here.
Keywords: brain; serial sectioning; human brain; brain samples ... See more keywords
Single-cell RNA sequencing analysis of human Alzheimer’s disease brain samples reveals neuronal and glial specific cells differential expression
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DOI: 10.1371/journal.pone.0277630
Abstract: Alzheimer’s disease is the most common neurological disease worldwide. Unfortunately, there are currently no effective treatment methods nor early detection methods. Furthermore, the disease underlying molecular mechanisms are poorly understood. Global bulk gene expression profiling… read more here.
Keywords: disease; alzheimer disease; expression; brain samples ... See more keywords
Application and Comparative Evaluation of Fluorescent Antibody, Immunohistochemistry and Reverse Transcription Polymerase Chain Reaction Tests for the Detection of Rabies Virus Antigen or Nucleic Acid in Brain Samples of Animals Suspected of Rabies in India
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary Sciences"
DOI: 10.3390/vetsci5010024
Abstract: Accurate and early diagnosis of animal rabies is critical for undertaking public health measures. Whereas the direct fluorescent antibody (DFA) technique is the recommended test, the more convenient, direct rapid immunochemistry test (dRIT), as well… read more here.
Keywords: brain samples; chain reaction; reverse transcription; polymerase chain ... See more keywords