P16.05 Implementation of a novel ex-vivo brain slice model to study human glioblastoma and glioma-associated microglia
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noab180.197
Abstract: Glioblastoma multiforme is a highly malignant brain tumor with a devastating prognosis. Resection followed by radio-chemotherapy leads to an overall survival of only 15 months. Up to 40% of the tumor mass consist of tumor-associated… read more here.
Keywords: glioma; vivo brain; brain slice; brain ... See more keywords
Abstract 4611: Leveraging organotypic brain slice models to enhance adoptive cellular therapies
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4611
Abstract: Glioblastoma (GBM) is an incredibly aggressive and prevalent primary CNS tumor with dismal survival outcomes. GBM’s intra-tumor heterogeneity and lack of anti-tumor immune cell infiltration have proved to be formidable challenges to the development of… read more here.
Keywords: brain slice; leveraging organotypic; slice models; tumor ... See more keywords
Development and validation of an advanced ex vivo brain slice invasion assay to model glioblastoma cell invasion into the complex brain microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.976945
Abstract: Organotypic cultures of murine brain slices are well-established tools in neuroscience research, including electrophysiology studies, modeling neurodegeneration, and cancer research. Here, we present an optimized ex vivo brain slice invasion assay that models glioblastoma multiforme… read more here.
Keywords: cell; brain slice; microscopy; brain ... See more keywords
Alternative Brain Slice-on-a-Chip for Organotypic Culture and Effective Fluorescence Injection Testing
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052549
Abstract: Mouse brain slices are one of the most common models to study brain development and functioning, increasing the number of study models that integrate microfluidic systems for hippocampal slice cultures. This report presents an alternative… read more here.
Keywords: injection; brain slice; brain; slice chip ... See more keywords