Brain Specific RagA Overexpression Triggers Depressive‐Like Behaviors in Mice via Activating ADORA2A Signaling Pathway
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202404188
Abstract: Neuroinflammation hallmarks the pathology of depression although the etiological complexity has not yet been resolved. Previous studies demonstrate that bacterial lipopolysaccharide induces depressive‐like behaviors by activating RagA‐mTOR‐p70S6K signaling pathway. The current project aims to investigate… read more here.
Keywords: like behaviors; raga overexpression; depressive like; signaling pathway ... See more keywords
Brain-specific TRAF7 deletion ameliorates traumatic brain injury by suppressing MEKK3-regulated glial inflammation and neuronal death.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108219
Abstract: Neuronal death and neuroinflammation play critical roles in regulating the progression of traumatic brain injury (TBI). However, associated pathogenesis has not been fully understood. Tumor necrosis factor receptor-associated factor 7 (TRAF7), as the unique noncanonical… read more here.
Keywords: brain specific; mekk3; brain; tbi ... See more keywords
Prenatal Origins of ASD: The When, What, and How of ASD Development
Sign Up to like & getrecommendations! Published in 2020 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2020.03.005
Abstract: Autism spectrum disorder (ASD) is a largely heritable, multistage prenatal disorder that impacts a child's ability to perceive and react to social information. Most ASD risk genes are expressed prenatally in many ASD-relevant brain regions… read more here.
Keywords: broadly expressed; prenatal origins; brain specific; asd ... See more keywords
Brain-specific functional relationship networks inform autism spectrum disorder gene prediction
Sign Up to like & getrecommendations! Published in 2018 at "Translational Psychiatry"
DOI: 10.1038/s41398-018-0098-6
Abstract: Autism spectrum disorder (ASD) is a neuropsychiatric disorder with strong evidence of genetic contribution, and increased research efforts have resulted in an ever-growing list of ASD candidate genes. However, only a fraction of the hundreds… read more here.
Keywords: specific functional; disorder; spectrum disorder; brain specific ... See more keywords
Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22751-7
Abstract: Lipid shuttling between neurons and glia contributes to the development, function, and stress responses of the nervous system. To understand how a neuron acquires its lipid supply from specific lipoproteins and their receptors, we perform… read more here.
Keywords: brain specific; mediate neuron; lipid shuttling; astrocyte derived ... See more keywords
Use of high-sensitivity digital ELISA improves the diagnostic performance of circulating brain-specific proteins for detection of traumatic brain injury during triage
Sign Up to like & getrecommendations! Published in 2020 at "Neurological Research"
DOI: 10.1080/01616412.2020.1726588
Abstract: ABSTRACT Background: Historically, limited sensitivity associated with traditional immunoassay methods has prevented the use of brain-specific proteins as blood biomarkers of traumatic brain injury (TBI) during triage, as these proteins exhibit low circulating concentrations. Digital… read more here.
Keywords: specific proteins; digital elisa; brain specific; brain ... See more keywords
Persistent Neuroinflammation and Brain Specific Immune Priming in A Novel Survival Model of Murine Pneumosepsis.
Sign Up to like & getrecommendations! Published in 2019 at "Shock"
DOI: 10.1097/shk.0000000000001435
Abstract: Pneumonia is the leading cause of sepsis and septic shock. Patients who survive pneumonia are vulnerable to long-term complications including increased risk of neurocognitive dysfunction. This study investigated the immune response and long-term complications of… read more here.
Keywords: brain specific; murine pneumosepsis; model; pneumosepsis ... See more keywords
ARP-1 Regulates the Transcriptional Activity of the Aromatase Gene in the Mouse Brain
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.00306
Abstract: An important function of aromatase in the brain is conversion of testosterone secreted from the testis into estradiol. Estradiol produced in the brain is thought to be deeply involved in the formation of sexually dimorphic… read more here.
Keywords: aro aii; brain specific; brain; aromatase ... See more keywords
FeatSNP: An Interactive Database for Brain-Specific Epigenetic Annotation of Human SNPs
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2019.00262
Abstract: FeatSNP is an online tool and a curated database for exploring 81 million common SNPs’ potential functional impact on the human brain. FeatSNP uses the brain transcriptomes of the human population to improve functional annotation… read more here.
Keywords: annotation human; specific epigenetic; brain specific; database ... See more keywords
Interplay between brain-specific microRNAs and Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2025 at "Neural regeneration research"
DOI: 10.4103/nrr.nrr-d-25-00190
Abstract: Alzheimer's disease is a progressive neurodegenerative disease characterized by memory decline and the accumulation of abnormal protein aggregates in the brain. While the precise cause of Alzheimer's disease remains under investigation, recent research suggests that… read more here.
Keywords: alzheimer disease; disease; specific micrornas; mir ... See more keywords