Biomimetic Lipopolysaccharide-Free Bacterial Outer Membrane-Functionalized Nanoparticles for Brain-Targeted Drug Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202105854
Abstract: The blood-brain barrier (BBB) severely blocks the intracranial accumulation of most systemic drugs. Inspired by the contribution of the bacterial outer membrane to Escherichia coli K1 (EC-K1) binding to and invasion of BBB endothelial cells… read more here.
Keywords: bacterial outer; membrane; brain targeted; outer membrane ... See more keywords
Engineered versus hybrid cellular vesicles as efficient drug delivery systems: a comparative study with brain targeted vesicles.
Sign Up to like & getrecommendations! Published in 2021 at "Drug delivery and translational research"
DOI: 10.1007/s13346-021-00900-1
Abstract: Herein we elaborated on methods to load cellular vesicles (CVs) and to incorporate cholesterol (Chol) and PEG lipids in their membrane, for enhancing the potential of such engineered CVs (e-CVs) as drug carriers. Hybrids formed… read more here.
Keywords: brain targeted; cvs; drug delivery; drug ... See more keywords
Brain-targeted gene delivery of ZnO quantum dots nanoplatform for the treatment of Parkinson disease
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2021.132210
Abstract: Abstract Accumulation of α-synuclein (SNCA) in the midbrain is considered as a major pathological characteristic of Parkinson's disease (PD). Inhibiting SNCA expression is an efficient approach in PD treatment. Here, we developed a novel brain-targeted… read more here.
Keywords: brain targeted; treatment; parkinson disease; zno quantum ... See more keywords
Brain-targeted Near-Infrared Nanobeacon for In Situ Monitoring H2S Fluctuation during Epileptic Seizures.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03254
Abstract: Epilepsy is a neurological brain disease, and its recurrent seizures are related to the reductive substance-powered antioxidant defense system (ADS). However, until now, there has been no report on the study of in situ antioxidant… read more here.
Keywords: situ; brain targeted; h2s fluctuation; near infrared ... See more keywords
Short Peptide-Mediated Brain-Targeted Drug Delivery with Enhanced Immunocompatibility.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b01216
Abstract: Peptide ligands have been exploited as versatile tools to facilitate targeted delivery of nanocarriers. However, the effects of peptide ligands on immunocompatibility and therapeutic efficacy of liposomes remain intricate. Here, a short and stable brain… read more here.
Keywords: brain targeted; delivery; slip dox; mediated brain ... See more keywords
High-efficiency brain-targeted intranasal delivery of BDNF mediated by engineered exosomes to promote remyelination.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00518b
Abstract: The regeneration of myelin sheaths is the ultimate goal of the treatment of demyelination disease, including multiple sclerosis (MS). However, current drugs for MS mainly target the immune system and can only slow down the… read more here.
Keywords: remyelination; brain targeted; brain; bdnf ... See more keywords
Brain-targeted lycopene-loaded microemulsion modulates neuroinflammation, oxidative stress, apoptosis and synaptic plasticity in β-amyloid-induced Alzheimer's disease mice.
Sign Up to like & getrecommendations! Published in 2023 at "Neurological research"
DOI: 10.1080/01616412.2023.2203615
Abstract: OBJECTIVES β-Amyloid protein (Aβ) plays pivotal roles in pathogenesis of Alzheimer's disease (AD) and triggers various pathophysiological events. Lycopene is a promising neuroprotector with multiple bioactivities, while its bioavailability is limited. Lycopene-loaded microemulsion (LME) possessing… read more here.
Keywords: brain targeted; brain; lycopene; mice ... See more keywords
Brain targeted delivery of lurasidone HCl via nasal administration of mucoadhesive nanoemulsion formulation for the potential management of schizophrenia
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2020.1772292
Abstract: Abstract This investigation aimed to design, develop, and optimize intranasal nanoemulsion for brain targeted delivery of lurasidone hydrochloride for the management and treatment of schizophrenia. The design of experiment supported optimization of high-pressure homogenization (HPH)… read more here.
Keywords: brain targeted; schizophrenia; nanoemulsion; lurasidone ... See more keywords
Brain Targeted Xenon Protects Cerebral Vasculature After Traumatic Brain Injury.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurotrauma"
DOI: 10.1089/neu.2022.0468
Abstract: Cerebrovascular dysfunction following traumatic brain injury (TBI) is a well characterized phenomenon. Given the therapeutic potential of xenon, we aimed to study its effects after localized delivery to the brain using microbubbles. We designed xenon… read more here.
Keywords: traumatic brain; brain targeted; brain; brain injury ... See more keywords
Cyclovirobuxine D Brain-Targeted Liposomes Improve Cerebral Ischemia-Reperfusion Injury via Anti-Oxidant Stress and Activating Autophagy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2022.3327
Abstract: One of the main issues faced by nervous system diseases is that drugs are difficult to enter the brain. The previous study suggested that Cyclovirobuxine D (CVBD) encapsulated in Angiopep-conjugated Polysorbate 80-Coated Liposomes showed a… read more here.
Keywords: cell; stress; brain targeted; targeted liposomes ... See more keywords
Long-Circulation and Brain Targeted Isoliquiritigenin Micelle Nanoparticles: Formation, Characterization, Tissue Distribution, Pharmacokinetics and Effects for Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s368528
Abstract: Purpose We designed a novel isoliquiritigenin (ISL) loaded micelle prepared with DSPE-PEG2000 as the drug carrier modified with the brain-targeting polypeptide angiopep-2 to improve the poor water solubility and low bioavailability of ISL for the… read more here.
Keywords: brain targeted; isl; brain; drug ... See more keywords