Biomimetic Lipopolysaccharide-Free Bacterial Outer Membrane-Functionalized Nanoparticles for Brain-Targeted Drug Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202105854
Abstract: The blood-brain barrier (BBB) severely blocks the intracranial accumulation of most systemic drugs. Inspired by the contribution of the bacterial outer membrane to Escherichia coli K1 (EC-K1) binding to and invasion of BBB endothelial cells… read more here.
Keywords: bacterial outer; membrane; brain targeted; outer membrane ... See more keywords
Engineered versus hybrid cellular vesicles as efficient drug delivery systems: a comparative study with brain targeted vesicles.
Sign Up to like & getrecommendations! Published in 2021 at "Drug delivery and translational research"
DOI: 10.1007/s13346-021-00900-1
Abstract: Herein we elaborated on methods to load cellular vesicles (CVs) and to incorporate cholesterol (Chol) and PEG lipids in their membrane, for enhancing the potential of such engineered CVs (e-CVs) as drug carriers. Hybrids formed… read more here.
Keywords: brain targeted; cvs; drug delivery; drug ... See more keywords
Peptide-functionalized nanoparticles for brain-targeted therapeutics.
Sign Up to like & getrecommendations! Published in 2025 at "Drug delivery and translational research"
DOI: 10.1007/s13346-025-01840-w
Abstract: Despite the rapid development of nanoparticle (NP)-based drug delivery systems, intravenous delivery of drugs to the brain remains a major challenge due to various biological barriers. To achieve therapeutic effects, NP-encapsulated drugs must avoid accumulation… read more here.
Keywords: brain targeted; brain; peptide functionalized; nanoparticles brain ... See more keywords
Brain-targeted gene delivery of ZnO quantum dots nanoplatform for the treatment of Parkinson disease
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2021.132210
Abstract: Abstract Accumulation of α-synuclein (SNCA) in the midbrain is considered as a major pathological characteristic of Parkinson's disease (PD). Inhibiting SNCA expression is an efficient approach in PD treatment. Here, we developed a novel brain-targeted… read more here.
Keywords: brain targeted; treatment; parkinson disease; zno quantum ... See more keywords
Brain-targeted Near-Infrared Nanobeacon for In Situ Monitoring H2S Fluctuation during Epileptic Seizures.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03254
Abstract: Epilepsy is a neurological brain disease, and its recurrent seizures are related to the reductive substance-powered antioxidant defense system (ADS). However, until now, there has been no report on the study of in situ antioxidant… read more here.
Keywords: situ; brain targeted; h2s fluctuation; near infrared ... See more keywords
Revolutionizing Neurological Therapies: The Multifaceted Potential of Zein-Based Nanoparticles for Brain-Targeted Drug Delivery.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.5c00062
Abstract: Zein nanoparticles (ZNPs) have gained significant attention as biocompatible and biodegradable nanocarrier systems for brain-targeted drug delivery. Their ability to encapsulate hydrophobic drugs and undergo surface modifications enables effective blood-brain barrier (BBB) penetration through receptor-mediated… read more here.
Keywords: brain targeted; drug; drug delivery; targeted drug ... See more keywords
Short Peptide-Mediated Brain-Targeted Drug Delivery with Enhanced Immunocompatibility.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b01216
Abstract: Peptide ligands have been exploited as versatile tools to facilitate targeted delivery of nanocarriers. However, the effects of peptide ligands on immunocompatibility and therapeutic efficacy of liposomes remain intricate. Here, a short and stable brain… read more here.
Keywords: brain targeted; delivery; slip dox; mediated brain ... See more keywords
Therapeutic Efficacy of a Synthetic Brain-Targeted H2S Donor Cross-Linked Nanomicelle in Autism Spectrum Disorder Rats through Aerobic Glycolysis.
Sign Up to like & getrecommendations! Published in 2024 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.4c11663
Abstract: Autism spectrum disorder (ASD) is characterized by cognitive inflexibility and social deficits, with a notably limited range of brain-targeted medications, particularly in the field of nanomedicine. Herein, we introduce the brain-targeted H2S donor cross-linked nanomicelle,… read more here.
Keywords: brain targeted; aerobic glycolysis; spectrum disorder; autism spectrum ... See more keywords
High-efficiency brain-targeted intranasal delivery of BDNF mediated by engineered exosomes to promote remyelination.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00518b
Abstract: The regeneration of myelin sheaths is the ultimate goal of the treatment of demyelination disease, including multiple sclerosis (MS). However, current drugs for MS mainly target the immune system and can only slow down the… read more here.
Keywords: remyelination; brain targeted; brain; bdnf ... See more keywords
Brain-targeted lycopene-loaded microemulsion modulates neuroinflammation, oxidative stress, apoptosis and synaptic plasticity in β-amyloid-induced Alzheimer's disease mice.
Sign Up to like & getrecommendations! Published in 2023 at "Neurological research"
DOI: 10.1080/01616412.2023.2203615
Abstract: OBJECTIVES β-Amyloid protein (Aβ) plays pivotal roles in pathogenesis of Alzheimer's disease (AD) and triggers various pathophysiological events. Lycopene is a promising neuroprotector with multiple bioactivities, while its bioavailability is limited. Lycopene-loaded microemulsion (LME) possessing… read more here.
Keywords: brain targeted; brain; lycopene; mice ... See more keywords
Brain targeted delivery of lurasidone HCl via nasal administration of mucoadhesive nanoemulsion formulation for the potential management of schizophrenia
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2020.1772292
Abstract: Abstract This investigation aimed to design, develop, and optimize intranasal nanoemulsion for brain targeted delivery of lurasidone hydrochloride for the management and treatment of schizophrenia. The design of experiment supported optimization of high-pressure homogenization (HPH)… read more here.
Keywords: brain targeted; schizophrenia; nanoemulsion; lurasidone ... See more keywords