A Brain‐Targeting NIR‐II Ferroptosis System: Effective Visualization and Oncotherapy for Orthotopic Glioblastoma (Adv. Sci. 13/2023)
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206333
Abstract: Near‐infrared‐II (NIR‐II) ferroptosis activators offer promising potentials in in vivo theranostics of deep tumors, such as glioma. However, most cases are nonvisual iron‐based systems that are blind for in vivo precise theranostic study. Additionally, the… read more here.
Keywords: orthotopic glioblastoma; brain targeting; ferroptosis; nir ferroptosis ... See more keywords
Biocompatible mucoadhesive nanoparticles for brain targeting of ropinirole hydrochloride: Formulations, radiolabeling and biodistribution.
Sign Up to like & getrecommendations! Published in 2022 at "Biopolymers"
DOI: 10.1002/bip.23489
Abstract: Two nanoformulations with mucoadhesive properties and brain-targeting mechanisms were designed to deliver the anti-Parkinson's drug, ropinirole hydrochloride (RH). In the first formulation, RH and the amphiphilic block copolymer methoxy poly(ethylene glycol)-b-poly(caprolactone) were assembled in a… read more here.
Keywords: administration; brain targeting; biodistribution; ropinirole hydrochloride ... See more keywords
Brain-targeting drug delivery systems.
Sign Up to like & getrecommendations! Published in 2022 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1818
Abstract: Brain diseases, including neurodegenerative diseases, acute ischemic stroke and brain tumors, have become a major health problem and a huge burden on society with high morbidity and mortality. However, most of the current therapeutic drugs… read more here.
Keywords: brain targeting; delivery systems; brain; drug ... See more keywords
Efficient neuronal targeting and transfection using RVG and transferrin-conjugated liposomes
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2020.146738
Abstract: Effective transport of therapeutic nucleic acid to brain has been a challenge for the success of gene therapy for treating brain diseases. In this study, we proposed liposomal nanoparticles modified with brain targeting ligandsfor active… read more here.
Keywords: targeting transfection; neuronal targeting; efficient neuronal; transferrin ... See more keywords
Brain targeting efficiency of antimigrain drug loaded mucoadhesive intranasal nanoemulsion.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.07.030
Abstract: Zolmitriptan (ZT) is a well-tolerated drug in migraine treatment suffering from low bioavailability due to low amount of the drug that reaches the brain after oral and nasal delivery. Development of new nasal mucoadhesive nanoemulsion… read more here.
Keywords: targeting efficiency; drug; mucoadhesive nanoemulsion; brain ... See more keywords
Borneol and poly (ethylene glycol) dual modified BSA nanoparticles as an itraconazole vehicle for brain targeting.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.119002
Abstract: Itraconazole (ITZ) can be used for the treatment of cryptococcus neoformans meningitis and aspergillus brain abscess. While, the inherent hydrophobicity of ITZ and the existence of blood brain barrier (BBB) limit its applications as a… read more here.
Keywords: itz nps; dual modified; bsa nanoparticles; itz ... See more keywords
Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review
Sign Up to like & getrecommendations! Published in 2023 at "IET Nanobiotechnology"
DOI: 10.1049/nbt2.12127
Abstract: Abstract Alzheimer's disease (AD) is one of the chief neurological difficulties in the aged population, identified through dementia, memory disturbance, and reduced cognitive abilities. β‐amyloid (Aβ) plaques aggregations, generation of reactive oxygen species, and mitochondrial… read more here.
Keywords: targeting based; alzheimer disease; brain targeting; brain ... See more keywords
In vitro and in vivo evaluation of cubosomal in situ nasal gel containing resveratrol for brain targeting
Sign Up to like & getrecommendations! Published in 2017 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2017.1338721
Abstract: Abstract The aim of this study was to enhance the delivery of resveratrol to the brain through the transnasal route by cubosomes. Cubosomes were prepared using glycerol monooleate and Lutrol F127 by probe sonication method.… read more here.
Keywords: resveratrol brain; gel containing; gel; brain ... See more keywords
Intranasal drug delivery of sumatriptan succinate-loaded polymeric solid lipid nanoparticles for brain targeting
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2022.2090575
Abstract: Abstract Migraine is a frequent neurological condition characterized by throbbing headaches, nausea, photophobia, and phonophobia, among other symptoms. Sumatriptan belongs to a BCS class III, which exhibits poor oral bioavailability and several side-effects. The objective… read more here.
Keywords: brain targeting; microscopy; brain; sumatriptan succinate ... See more keywords
Cysteine Donor-Based Brain-Targeting Prodrug: Opportunities and Challenges
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/4834117
Abstract: Overcoming blood-brain barrier (BBB) to improve brain bioavailability of therapeutic drug remains an ongoing concern. Prodrug is one of the most reliable approaches for delivering agents with low-level BBB permeability into the brain. The well-known… read more here.
Keywords: bbb; brain targeting; brain; based brain ... See more keywords
Patient-Friendly, Olfactory-Targeted, Stimuli-Responsive Hydrogels for Cerebral Degenerative Disorders Ensured > 400% Brain Targeting Efficiency in Rats.
Sign Up to like & getrecommendations! Published in 2020 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-020-01872-0
Abstract: Non-invasive brain therapy for chronic neurological disorders is in high demand. Vinpocetine (VIN) tablets for cerebrovascular degenerative disorders ensued 8 h, while CP-HPMC-SA hydrogels were mucoadhesive in simulated nasal fluid, owing to pH and ion-activated gelation.… read more here.
Keywords: hpmc; degenerative disorders; targeting efficiency; brain ... See more keywords