Multidimensional Proteomic Landscape Reveals Distinct Activated Pathways Between Human Brain Tumors
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202410142
Abstract: Brain metastases (BrMs) and gliomas are two typical human brain tumors with high incidence of mortalities and distinct clinical challenges, yet the understanding of these two types of tumors remains incomplete. Here, a multidimensional proteomic… read more here.
Keywords: proteomic landscape; brain; human brain; brain tumors ... See more keywords
Personalized fMRI Delineates Functional Regions Preserved within Brain Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26303
Abstract: Accumulating evidence from invasive cortical stimulation mapping and noninvasive neuroimaging studies indicates that brain function may be preserved within brain tumors. However, a noninvasive approach to accurately and comprehensively delineate individual‐specific functional networks in the… read more here.
Keywords: functional regions; within brain; brain tumors; brain ... See more keywords
Genetic alterations of IDH1 and Vegf in brain tumors
Sign Up to like & getrecommendations! Published in 2017 at "Brain and Behavior"
DOI: 10.1002/brb3.718
Abstract: This study evaluates the presence of R132H mutation in isocitrate dehydrogenase (IDH1) gene and the vascular endothelial growth factor (VEGF) +936 C/T polymorphism in brain tumors. The impact of these genetic alterations on overall survival… read more here.
Keywords: vegf brain; idh1 vegf; genetic alterations; alterations idh1 ... See more keywords
In vivo imaging xenograft models for the evaluation of anti‐brain tumor efficacy of targeted drugs
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Medicine"
DOI: 10.1002/cam4.1255
Abstract: Molecular‐targeted drugs are generally effective against tumors containing driver oncogenes, such as EGFR, ALK, and NTRK1. However, patients harboring these oncogenes frequently experience a progression of brain metastases during treatment. Here, we present an in… read more here.
Keywords: progression; vivo imaging; targeted drugs; brain ... See more keywords
Immunotherapy approaches in the treatment of malignant brain tumors
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DOI: 10.1002/cncr.30371
Abstract: Glioblastoma is the most common malignant primary brain tumor. Despite standard‐of‐care treatment, consisting of maximal surgical resection followed by chemoradiation, both morbidity and mortality associated with this disease remain very poor. Therefore, there is an… read more here.
Keywords: treatment; immunotherapy approaches; cancer; brain ... See more keywords
Advances in the classification of pediatric brain tumors through DNA methylation profiling: From research tool to frontline diagnostic
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DOI: 10.1002/cncr.31583
Abstract: Despite significant improvements in pediatric brain tumor therapy and outcome, too many children still die of disease, and too many survivors experience significant sequelae as a result of conventional therapies. The molecular characterization of pediatric… read more here.
Keywords: methylation profiling; brain; biology; pediatric brain ... See more keywords
Top advances of the year: Neuro‐oncology
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DOI: 10.1002/cncr.34711
Abstract: Management of brain tumors has been challenging given the limited therapeutic options and disabling morbidities associated with central nervous system (CNS) dysfunction. This review focuses on recent developments in the field, with an emphasis on… read more here.
Keywords: oncology; top advances; brain tumors; year neuro ... See more keywords
Phonological and surface dyslexia in individuals with brain tumors: Performance pre‐, intra‐, immediately post‐surgery and at follow‐up
Sign Up to like & getrecommendations! Published in 2020 at "Human Brain Mapping"
DOI: 10.1002/hbm.25176
Abstract: We address existing controversies regarding neuroanatomical substrates of reading‐aloud processes according to the dual‐route processing models, in this particular instance in a series of 49 individuals with brain tumors who performed several reading tasks of… read more here.
Keywords: individuals brain; surgery; surface dyslexia; brain ... See more keywords
Risk of childhood brain tumors after exposure to CT radiation: A nationwide population‐based case–control study in Finland
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Cancer"
DOI: 10.1002/ijc.35318
Abstract: In this nationwide population‐based case–control study, we assessed the risk of childhood brain tumors following exposure to radiation from CT. Brain tumors diagnosed in Finland during 1990–2016 were identified by the Finnish Cancer Registry. For… read more here.
Keywords: brain; brain tumors; population; risk childhood ... See more keywords
Combined germline pathogenic variants in FLCN and TP53 are associated with early onset renal cell carcinoma and brain tumors
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.2098
Abstract: We present a family consisting of a father and his two children with an exceptional phenotype of childhood renal cell carcinoma and brain tumors. Extensive genetic testing revealed two inherited tumor predisposition syndromes in all… read more here.
Keywords: cell carcinoma; renal cell; carcinoma brain; brain tumors ... See more keywords
Deep learning architecture with transformer and semantic field alignment for voxel-level dose prediction on brain tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Medical physics"
DOI: 10.1002/mp.16122
Abstract: PURPOSE The use of convolution neural networks (CNN) to accurately predict dose distributions can accelerate intensity-modulated radiation therapy (IMRT) planning. The purpose of our study is to develop a novel deep learning architecture for precise… read more here.
Keywords: level dose; voxel level; brain tumors; dose distributions ... See more keywords