The 3D Brain Unit Network Model to Study Spatial Brain Drug Exposure under Healthy and Pathological Conditions
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical Research"
DOI: 10.1007/s11095-020-2760-y
Abstract: Purpose We have developed a 3D brain unit network model to understand the spatial-temporal distribution of a drug within the brain under different (normal and disease) conditions. Our main aim is to study the impact… read more here.
Keywords: drug; brain ecf; unit network; brain unit ... See more keywords
A 3D brain unit model to further improve prediction of local drug distribution within the brain
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0238397
Abstract: The development of drugs targeting the brain still faces a high failure rate. One of the reasons is a lack of quantitative understanding of the complex processes that govern the pharmacokinetics (PK) of a drug… read more here.
Keywords: within brain; drug; model; brain unit ... See more keywords