Pharmacokinetics and brain uptake study of novel AMPA receptor antagonist perampanel in SD rats using a validated UHPLC‐QTOF‐MS method
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.11.008
Abstract: Graphical abstract Figure. No caption available. HighlightsThe method shows high sensitivity, very good precision and accuracy with short run time.Simple protein precipitation as sample preparation approach with good recovery from plasma/brain homogenate.The method found to… read more here.
Keywords: method; brain; perampanel rats; uptake study ... See more keywords
Brain uptake of deltamethrin in rats as a function of plasma protein binding and blood–brain barrier maturation
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2017.04.009
Abstract: HIGHLIGHTSHigh brain levels of pyrethroids result in increased neurotoxicity in immature rats.Low metabolic inactivation of parent pyrethroids results in elevated brain levels.Reduced protein binding in immature rats plasma is not sufficient to impact brain uptake.Brain… read more here.
Keywords: blood brain; protein binding; brain barrier; brain ... See more keywords
Brain uptake of multivalent and multi-specific DVD-Ig proteins after systemic administration
Sign Up to like & getrecommendations! Published in 2018 at "mAbs"
DOI: 10.1080/19420862.2018.1465159
Abstract: ABSTRACT Therapeutic monoclonal antibodies and endogenous IgG antibodies show limited uptake into the central nervous system (CNS) due to the blood-brain barrier (BBB), which regulates and controls the selective and specific transport of both exogenous… read more here.
Keywords: systemic administration; brain; brain uptake; dvd proteins ... See more keywords
Investigating brain uptake of a non-targeting monoclonal antibody after intravenous and intracerebroventricular administration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.958543
Abstract: Monoclonal antibodies play an important role in the treatment of various diseases. However, the development of these drugs against neurological disorders where the drug target is located in the brain is challenging and requires a… read more here.
Keywords: brain uptake; administration; csf; brain ... See more keywords
Pretargeted Imaging beyond the Blood–Brain Barrier—Utopia or Feasible?
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15101191
Abstract: Pretargeting is a promising nuclear imaging technique that allows for the usage of antibodies (Abs) with enhanced imaging contrast and reduced patient radiation burden. It is based on bioorthogonal chemistry with the tetrazine ligation—a reaction… read more here.
Keywords: brain uptake; beyond blood; contrast; brain ... See more keywords