The Role of Brain Vasculature in Glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-1561-y
Abstract: For normal functioning, the brain requires an adequate supply of blood. The components of normal brain vasculature are collectively referred to as the neurovascular unit. When the brain develops pathology, the structural and functional components… read more here.
Keywords: glioblastoma; vasculature; role brain; brain vasculature ... See more keywords
VPS28 regulates brain vasculature by controlling neuronal VEGF trafficking through extracellular vesicle secretion
Sign Up to like & getrecommendations! Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2022.104042
Abstract: Summary Extracellular vesicles (EVs) participate in intercellular communication and contribute to the angiogenesis. However, the understanding of the mechanisms underlying EVs secretion by neurons and their action on the vascular system of the central nervous… read more here.
Keywords: vegf trafficking; brain; secretion; brain vasculature ... See more keywords
Interactive visualization and analysis of morphological skeletons of brain vasculature networks with VessMorphoVis
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa461
Abstract: Abstract Motivation Accurate morphological models of brain vasculature are key to modeling and simulating cerebral blood flow in realistic vascular networks. This in silico approach is fundamental to revealing the principles of neurovascular coupling. Validating… read more here.
Keywords: interactive visualization; analysis; visualization; brain vasculature ... See more keywords
Brain vasculature disturbance in schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Psychiatry"
DOI: 10.1097/yco.0000000000000789
Abstract: Purpose of review The vascular hypothesis of schizophrenia (SZ) postulates that brain endothelial dysfunction contributes to brain pathophysiology. This review discusses recent evidence for and against this hypothesis, including data related to blood–brain barrier (BBB),… read more here.
Keywords: vasculature disturbance; brain vasculature; brain endothelium; endothelium ... See more keywords
Neuromodulation by cerebrovasculature BDNF: is it much greater than we think?
Sign Up to like & getrecommendations! Published in 2017 at "Acta Physiologica"
DOI: 10.1111/apha.12823
Abstract: The findings published by Monnier et al. (2016) in this journal showing substantial cerebrovascular BDNF synthesis are very interesting and could change our way we perceive BDNF production in the brain under normal and disease… read more here.
Keywords: production; control; brain vasculature; brain ... See more keywords
Hepatic leukemia factor-expressing paraxial mesoderm cells contribute to the developing brain vasculature
Sign Up to like & getrecommendations! Published in 2022 at "Biology Open"
DOI: 10.1242/bio.059510
Abstract: ABSTRACT Recent genetic lineage tracing studies reveal heterogeneous origins of vascular endothelial cells and pericytes in the developing brain vasculature, despite classical experimental evidence for a mesodermal origin. Here we provide evidence through a genetic… read more here.
Keywords: brain vasculature; developing brain; brain; hepatic leukemia ... See more keywords
Retinoic Acid Regulates Endothelial β-catenin Expression and Pericyte Numbers in the Developing Brain Vasculature
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2018.00476
Abstract: The acquisition of brain vascular properties, like tight junctions and pericytes, to form the blood-brain barrier (BBB) is crucial for a properly functioning central nervous system (CNS). Endothelial WNT signaling is a known driver of… read more here.
Keywords: expression; brain; wnt signaling; brain vasculature ... See more keywords
Structural and Functional Remodeling of the Brain Vasculature Following Stroke
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.00948
Abstract: Maintenance of cerebral blood vessel integrity and regulation of cerebral blood flow ensure proper brain function. The adult human brain represents only a small portion of the body mass, yet about a quarter of the… read more here.
Keywords: functional remodeling; following stroke; structural functional; brain vasculature ... See more keywords