Simultaneous Functional Magnetic Resonance and Optoacoustic Imaging of Brain‐Wide Sensory Responses in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202205191
Abstract: Functional magnetic resonance imaging (fMRI) has massively contributed to the understanding of mammalian brain function. However, the origin and interpretation of the blood oxygen level‐dependent (BOLD) signals retrieved by fMRI remain highly disputed. This article… read more here.
Keywords: magnetic resonance; resonance optoacoustic; brain; functional magnetic ... See more keywords
Brain‐wide network analysis of resting‐state neuromagnetic data
Sign Up to like & getrecommendations! Published in 2023 at "Human Brain Mapping"
DOI: 10.1002/hbm.26295
Abstract: The present study performed a brain‐wide network analysis of resting‐state magnetoencephalograms recorded from 53 healthy participants to visualize elaborate brain maps of phase‐ and amplitude‐derived graph‐theory metrics at different frequencies. To achieve this, we conducted… read more here.
Keywords: network; brain; resting state; analysis ... See more keywords
Link Brain-Wide Projectome to Neuronal Dynamics in the Mouse Brain
Sign Up to like & getrecommendations! Published in 2024 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-024-01232-z
Abstract: Knowledge about the neuronal dynamics and the projectome are both essential for understanding how the neuronal network functions in concert. However, it remains challenging to obtain the neural activity and the brain-wide projectome for the… read more here.
Keywords: projectome neuronal; brain; wide projectome; link brain ... See more keywords
Brain-wide Mapping of Endogenous Serotonergic Transmission via Chemogenetic fMRI.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.09.087
Abstract: Serotonin-producing neurons profusely innervate brain regions via long-range projections. However, it remains unclear whether and how endogenous serotonergic transmission specifically influences regional or global functional activity. We combined designed receptors exclusively activated by designed drugs (DREADD)-based chemogenetics… read more here.
Keywords: serotonergic transmission; serotonin; brain wide; endogenous serotonergic ... See more keywords
Brain-wide representations of ongoing behavior: a universal principle?
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2020.02.008
Abstract: Recent neuronal activity recordings of unprecedented breadth and depth in worms, flies, and mice have uncovered a surprising common feature: brain-wide behavior-related signals. These signals pervade, and even dominate, neuronal populations thought to function primarily… read more here.
Keywords: wide representations; principle; brain wide; brain ... See more keywords
Local hippocampal fast gamma rhythms precede brain-wide hyperemic patterns during spontaneous rodent REM sleep
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07752-3
Abstract: Rapid eye movement sleep (REMS) is a peculiar brain state combining the behavioral components of sleep and the electrophysiological profiles of wake. After decades of research our understanding of REMS still is precluded by the… read more here.
Keywords: rem sleep; fast gamma; brain wide; brain ... See more keywords
Brain-wide projection reconstruction of single functionally defined neurons.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29229-0
Abstract: Reconstructing axonal projections of single neurons at the whole-brain level is currently a converging goal of the neuroscience community that is fundamental for understanding the logic of information flow in the brain. Thousands of single… read more here.
Keywords: reconstruction; wide projection; brain wide; single neurons ... See more keywords
Unsupervised classification of brain-wide axons reveals the presubiculum neuronal projection blueprint
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-45741-x
Abstract: We present a quantitative strategy to identify all projection neuron types from a given region with statistically different patterns of anatomical targeting. We first validate the technique with mouse primary motor cortex layer 6 data,… read more here.
Keywords: classification; projection; unsupervised classification; brain wide ... See more keywords
Optogenetic activation of dorsal raphe serotonin neurons induces brain-wide activation
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-48489-6
Abstract: Serotonin is a neuromodulator that affects multiple behavioral and cognitive functions. Nonetheless, how serotonin causes such a variety of effects via brain-wide projections and various receptors remains unclear. Here we measured brain-wide responses to optogenetic… read more here.
Keywords: brain; wide activation; serotonin neurons; activation ... See more keywords
SOLID: minimizing tissue distortion for brain-wide profiling of diverse architectures
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-52560-7
Abstract: Brain-wide profiling of diverse biological components is fundamental for understanding complex brain pathology. Despite the availability in whole-brain imaging, it is still challenging to conduct multiplexed, brain-wide analysis with current tissue clearing techniques. Here, we… read more here.
Keywords: brain; tissue clearing; tissue distortion; brain wide ... See more keywords
Identifying the bioimaging features of Alzheimer’s disease based on pupillary light response-driven brain-wide fMRI in awake mice
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-53878-y
Abstract: Pupil dynamics has emerged as a critical non-invasive indicator of brain state changes. In particular, pupillary-light-responses (PLR) in Alzheimer’s disease (AD) patients show potential as biomarkers for brain degeneration. To investigate AD-specific PLR and its… read more here.
Keywords: mice; alzheimer disease; brain; pupil ... See more keywords