Taking the Brakes Off Targeted Protein Degradation.
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DOI: 10.1016/j.chembiol.2019.12.010
Abstract: PCSK9 heightens LDL cholesterol levels by chaperoning the liver LDL receptor to lysosomes for degradation. In this issue of Cell Chemical Biology, Petrilli et al. (2020) identify novel PCSK9 ligands and convert them into a proof-of-concept… read more here.
Keywords: taking brakes; brakes targeted; protein degradation; biology ... See more keywords