β-Branched Amino Acids Stabilize Specific Conformations of Cyclic Hexapeptides.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.12.015
Abstract: Cyclic peptides (CPs) are a promising class of molecules for drug development, particularly as inhibitors of protein-protein interactions. Predicting low-energy structures and global structural ensembles of individual CPs is critical for the design of bioactive… read more here.
Keywords: cyclic hexapeptides; amino acids; well structured; global structural ... See more keywords
From the Bench to the Bedside: Branched Amino Acid and Micronutrient Strategies to Improve Mitochondrial Dysfunction Leading to Sarcopenia
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14030483
Abstract: With extended life expectancy, the older population is constantly increasing, and consequently, so too is the prevalence of age-related disorders. Sarcopenia, the pathological age-related loss of muscle mass and function; and malnutrition, the imbalance in… read more here.
Keywords: bench bedside; mitochondrial dysfunction; branched amino; leading sarcopenia ... See more keywords