Mechanism and Inhibitor Exploration with Binuclear Mg Ketol‐Acid Reductoisomerase: Targeting the Biosynthetic Pathway of Branched‐Chain Amino Acids
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DOI: 10.1002/cbic.201900363
Abstract: Binuclear Mg ketol‐acid reductoisomerase (KARI), which converts (S)‐2‐acetolactate into (R)‐2,3‐dihydroxyisovalerate, is responsible for the second step of the biosynthesis of branched‐chain amino acids in plants and microorganisms and thus serves as a key inhibition target… read more here.
Keywords: binuclear ketol; mechanism; chain amino; branched chain ... See more keywords
Branched‐Chain Polyamine Found in Hyperthermophiles Induces Unique Temperature‐Dependent Structural Changes in Genome‐Size DNA
Sign Up to like & getrecommendations! Published in 2018 at "Chemphyschem"
DOI: 10.1002/cphc.201800396
Abstract: Abstract A pentavalent branched‐chain polyamine, N 4‐bis(aminopropyl)spermidine 3(3)(3)4, is a unique polycation found in the hyperthermophilic archaeon Thermococcus kodakarensis, which grows at temperatures between 60 and 100 °C. We studied the effects of this branched‐chain polyamine… read more here.
Keywords: chain; temperature; dna; branched chain ... See more keywords
Circulating branched‐chain amino acids and incident heart failure in type 2 diabetes: The Hong Kong Diabetes Register
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3253
Abstract: Levels of branched‐chain amino acids (BCAAs, namely, isoleucine, leucine, and valine) are modulated by dietary intake and metabolic/genetic factors. BCAAs are associated with insulin resistance and increased risk of type 2 diabetes (T2D). Although insulin… read more here.
Keywords: amino acids; chain amino; heart failure; branched chain ... See more keywords
Medium branched chain fatty acids improve the profile of tricarboxylic acid cycle intermediates in mitochondrial fatty acid β-oxidation deficient cells: A comparative study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of inherited metabolic disease"
DOI: 10.1002/jimd.12480
Abstract: Inherited errors of mitochondrial fatty acid β-oxidation (FAO) are life threatening, even with optimum care. FAO is the major source of energy for heart and is critical for skeletal muscles especially during physiologic stress. Clinical… read more here.
Keywords: chain; deficient; fatty acids; chain fatty ... See more keywords
Balanced Branched-Chain Amino Acids Modulate Meat Quality via Adjusting Muscle Fiber Type Conversion and Intramuscular Fat Deposition in Finishing Pigs.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11728
Abstract: BACKGROUND Pork is an important food for humans and improving the quality of pork is closely related to human health. This study was designed to investigate the effects of balanced branched-chain amino acids (BCAAs)-supplemented protein-restricted… read more here.
Keywords: muscle; meat quality; balanced branched; quality ... See more keywords
Overview of chromatographic and electrophoretic methods for the determination of branched-chain amino acids.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of separation science"
DOI: 10.1002/jssc.202300213
Abstract: The significance of branched-chain amino acids in diseases was clearly shown over the years. This review aims to describe the available techniques for their analytical determination. The article provides examples of the use of various… read more here.
Keywords: determination; amino acids; chain amino; branched chain ... See more keywords
Branched‐chain amino acid supplementation impairs insulin sensitivity and promotes lipogenesis during exercise in diet‐induced obese mice
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DOI: 10.1002/oby.23394
Abstract: Branched‐chain amino acids (BCAAs) are popular dietary supplements for exercise. However, increased BCAA levels positively correlate with obesity and diabetes. The metabolic impact of BCAA supplementation on insulin sensitivity during exercise is less understood. read more here.
Keywords: supplementation; chain amino; insulin sensitivity; branched chain ... See more keywords
Hepatic and serum branched‐chain fatty acid profile in patients with nonalcoholic fatty liver disease: A case–control study
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DOI: 10.1002/oby.23711
Abstract: Alterations in the hepatic lipidome are a crucial factor involved in the pathophysiology of nonalcoholic fatty liver disease (NAFLD). The aim of this study was to evaluate the serum and hepatic profile of branched‐chain fatty… read more here.
Keywords: nonalcoholic fatty; chain fatty; branched chain; fatty liver ... See more keywords
Quantification of Branched-Chain Alcohol-Based Biofuels and Other Fermentation Metabolites via High-Performance Liquid Chromatography.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1323-8_5
Abstract: As the consequences of climate change become apparent, metabolic engineers and synthetic biologists are exploring sustainable sources for transportation fuels. The design and engineering of microorganisms to produce bio-gasoline and other biofuels from renewable feedstocks… read more here.
Keywords: quantification branched; fermentation; branched chain; liquid chromatography ... See more keywords
Enhanced cerebral branched-chain amino acid metabolism in R6/2 mouse model of Huntington’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03051-2
Abstract: Huntington’s disease (HD) is a hereditary and fatal disease causing profound neurodegeneration. Deficits in cerebral energy and neurotransmitter metabolism have been suggested to play a central role in the neuronal dysfunction and death associated with… read more here.
Keywords: isoleucine; metabolism; huntington disease; chain amino ... See more keywords
Branched-chain dicationic ionic liquids for fatty acid methyl ester assessment by gas chromatography
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DOI: 10.1007/s00216-017-0722-y
Abstract: AbstractTwelve bis- or dicationic ionic liquids (ILs) including eight based on imidazolium, a single one based on phosphonium, and three based on pyrrolidinium cationic units were prepared with the bis(trifluoromethyl sulfonyl) imide anion. The two… read more here.
Keywords: column; chain dicationic; fatty acid; branched chain ... See more keywords