TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.01.023
Abstract: Targeted protein degradation is an emerging therapeutic paradigm. Small-molecule degraders such as proteolysis-targeting chimeras (PROTACs) induce the degradation of neo-substrates by hijacking E3 ubiquitin ligases. Although ubiquitylation of endogenous substrates has been extensively studied, the… read more here.
Keywords: k29 k48; degradation; k48 branched; branched ubiquitin ... See more keywords
Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14274
Abstract: Ubiquitination of a subset of proteins by ubiquitin chain elongation factors (E4), represented by Ufd2p in Saccharomyces cerevisiae, is a pivotal regulator for many biological processes. However, the mechanism of Ufd2p-mediated ubiquitination is largely unclear.… read more here.
Keywords: substrates modified; degradation; ubiquitin chain; branched ubiquitin ... See more keywords