A novel LysR‐type regulator negatively affects biosynthesis of the immunosuppressant brasilicardin
Sign Up to like & getrecommendations! Published in 2021 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.202000038
Abstract: Brasilicardin A (BraA) is a promising immunosuppressive compound produced naturally by the pathogenic bacterium Nocardia terpenica IFM 0406. Heterologous host expression of brasilicardin gene cluster showed to be efficient to bypass the safety issues, low… read more here.
Keywords: bra bgc; brasilicardin; lysr type; gene ... See more keywords
Synthesis of a Complex Brasilicardin Analogue Utilizing a Cobalt-Catalyzed MHAT-Induced Radical Bicyclization Reaction
Sign Up to like & getrecommendations! Published in 2023 at "Organic Letters"
DOI: 10.1021/acs.orglett.3c01019
Abstract: We designed and executed an expedient synthesis of a complex analogue of the potent immunosuppressive natural product brasilicardin A. Our successful synthesis featured application of our recently developed MHAT-initiated radical bicyclization, which delivered the targeted,… read more here.
Keywords: radical bicyclization; synthesis complex; brasilicardin; analogue ... See more keywords