Genetic variant strains of Leishmania (Viannia) braziliensis exhibit distinct biological behaviors
Sign Up to like & getrecommendations! Published in 2018 at "Parasitology Research"
DOI: 10.1007/s00436-018-6014-4
Abstract: A variety of clinical forms of American cutaneous leishmaniasis (ACL) caused by Leishmania braziliensis, as well as differing immune responses of patients, have been reported for an ACL focus in the state of Minas Gerais,… read more here.
Keywords: strains leishmania; variant strains; leishmania viannia; braziliensis ... See more keywords
In vitro evaluation and in vivo efficacy of nitroimidazole-sulfanyl ethyl derivatives against Leishmania (V.) braziliensis and Leishmania (L.) mexicana.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology research"
DOI: 10.1007/s00436-021-07266-w
Abstract: The aim of this study was to synthesize several small molecules of the type 5-nitroimidazole-sulfanyl and evaluate biological properties against the main Leishmania species that cause cutaneous leishmaniasis in Venezuela. Final compounds 4-7 were generated… read more here.
Keywords: braziliensis; nitroimidazole sulfanyl; evaluation; leishmania mexicana ... See more keywords
Paleoclimatic distribution and phylogeography of Mussismilia braziliensis (Anthozoa, Scleractinia), an endemic Brazilian reef coral
Sign Up to like & getrecommendations! Published in 2020 at "Marine Biodiversity"
DOI: 10.1007/s12526-020-01063-x
Abstract: Studies suggest that Pleistocene sea-level fluctuations have drastically affected shallow marine ecosystems such as coral reefs. In the Southwest Atlantic, a Seamounts chain near the Abrolhos Bank has been hypothesized as a stable climatic refugium… read more here.
Keywords: braziliensis; paleoclimatic distribution; distribution; phylogeography ... See more keywords
Histone deacetylases inhibitors as new potential drugs against Leishmania braziliensis, the main causative agent of New World Tegumentary Leishmaniasis.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114191
Abstract: The protozoan parasite Leishmania braziliensis is a major causative agent of the neglected tropical diseases Cutaneous and Mucocutaneous Leishmaniases in the New World. There are no vaccines to prevent the infection and the treatment relies… read more here.
Keywords: leishmania braziliensis; new world; braziliensis; causative agent ... See more keywords
Brazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensis.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2016.09.014
Abstract: American Tegumentar Leishmaniasis (ATL) is an infectious disease caused by Leishmania parasites with ineffective treatment. The properties of propolis have been studied in different experimental studies, however, few works have investigated the effects of propolis… read more here.
Keywords: american tegumentar; leishmaniasis; braziliensis; propolis ... See more keywords
Design, synthesis, structure-activity relationship and mechanism of action studies of a series of 4-chloro-1-phthalazinyl hydrazones as a potent agent against Leishmania braziliensis.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.01.022
Abstract: With the aim to identify a potential drug candidate to treat cutaneous leishmaniasis, a series of 1-phthalazinyl hydrazones were synthesized and tested against Leishmania braziliensis parasite, one of the main responsible of this disease in… read more here.
Keywords: leishmania braziliensis; braziliensis; phthalazinyl hydrazones; activity relationship ... See more keywords
Photodynamic therapy using ultradeformable liposomes loaded with chlorine aluminum phthalocyanine against L. (V.) braziliensis experimental models.
Sign Up to like & getrecommendations! Published in 2018 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2018.09.016
Abstract: Ultradeformable liposomes (UDLs) containing sodium cholate as edge activator could be an appropriate skin drug-delivery system for chloroaluminum phthalocyanine (ClAlPc) during photodynamic therapy (PDT) against cutaneous leishmaniasis (CL). The aim of this work was to… read more here.
Keywords: clalpc; photodynamic therapy; experimental models; braziliensis ... See more keywords
Kinetic and oligomeric study of Leishmania braziliensis nicotinate/nicotinamide mononucleotide adenylyltransferase
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DOI: 10.1016/j.heliyon.2020.e03733
Abstract: Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme involved in REDOX reactions and oxidative stress defense systems. Furthermore, NAD is used as substrate by proteins that regulate essential cellular functions as DNA repair, genetic, and… read more here.
Keywords: leishmania braziliensis; nicotinamide mononucleotide; braziliensis; lbnmnat protein ... See more keywords
In vitro effect of Bothrops leucurus lectin (BLL) against Leishmania amazonensis and Leishmania braziliensis infection.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.08.064
Abstract: Leishmania amazonensis and Leishmania braziliensis are the main causative agents of American Tegumentary Leishmaniasis (ATL) in Brazil. As intracellular parasites, the infection by Leishmania species is dependent on the host immune response and the immunotherapy… read more here.
Keywords: braziliensis; leishmania amazonensis; bll; amazonensis leishmania ... See more keywords
Impact of collaborative actions of Leishmania (Viannia) braziliensis subpopulations on the infection profile
Sign Up to like & getrecommendations! Published in 2022 at "Parasitology"
DOI: 10.1017/s003118202200097x
Abstract: Abstract Abstract This study focuses on the role of the population structure of Leishmania spp. on the adaptive capacity of the parasite. Herein, we investigate the contribution of subpopulations of the L. (V.) braziliensis Thor… read more here.
Keywords: thor22 combinations; infection profile; infection; braziliensis ... See more keywords
Functional Study of Leishmania braziliensis Protein Arginine Methyltransferases (PRMTs) Reveals That PRMT1 and PRMT5 Are Required for Macrophage Infection.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.1c00509
Abstract: In trypanosomatids, regulation of gene expression occurs mainly at the posttranscriptional level, and RNA-binding proteins (RBPs) are key players in determining the fates of transcripts. RBPs are targets of protein arginine methyltransferases (PRMTs), which posttranslationally… read more here.
Keywords: methylation; protein arginine; methyltransferases prmts; braziliensis ... See more keywords