Divergent binding mode for a protozoan BRC repeat to RAD51
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1101/2022.01.25.477309
Abstract: Interaction of BRCA2 through ca. 30 amino acid residue motifs, BRC repeats, with RAD51 is a conserved feature of the double-strand DNA break repair process in eukaryotes. In humans the binding of the eight BRC… read more here.
Keywords: repeat; brc; brc repeat; brc repeats ... See more keywords
Abstract 5603: Defining the functions of the BRCA2 BRC repeats in modulating RAD51 binding and activity
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-5603
Abstract: The BRCA2 (Breast Cancer Susceptibility 2) gene is critical for preserving genome integrity by regulating homology-directed repair (HDR) of DNA double-strand breaks (DSBs). Germline mutations in BRCA2 predispose individuals to a high risk for ovarian,… read more here.
Keywords: brc repeats; brc repeat; cancer; rad51 binding ... See more keywords