Ethnic‐specificity, evolution origin and deleteriousness of Asian BRCA variation revealed by over 7500 BRCA variants derived from Asian population
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34359
Abstract: Pathogenic variation in BRCA1 and BRCA2 (BRCA) causes high risk of breast and ovarian cancer, and BRCA variation data are important markers for BRCA‐related clinical cancer applications. However, comprehensive BRCA variation data are lacking from… read more here.
Keywords: brca variation; asian brca; variation; asian population ... See more keywords
Sichere Schwangerschaft nach Brustkrebstherapie von BRCA-Mutations-Trägerinnen?
Sign Up to like & getrecommendations! Published in 2020 at "Strahlentherapie und Onkologie"
DOI: 10.1007/s00066-020-01726-5
Abstract: Hintergrund Breast-Cancer(BRCA)-Keimbahnmutationen stellen für junge Frauen besondere reproduktive Herausforderungen dar. Eine Schwangerschaft nach Brustkrebs erhöht zwar das Rückfallrisiko nicht; allerdings liegen nur sehr begrenzt Daten von Schwangerschaften bei Patientinnen mit BRCA-Mutationen vor. Die Studie untersuchte… read more here.
Keywords: sichere schwangerschaft; von; schwangerschaft nach; nach brustkrebstherapie ... See more keywords
BRCA testing and outcomes in women with breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-020-06038-x
Abstract: Main purpose Germline BRCA mutations ( BRCA m) strongly influence the risk of developing breast cancer. This study aimed to understand the role of BRCA m testing in affected individuals and to assess its impact… read more here.
Keywords: study; breast cancer; women breast; brca ... See more keywords
Helping Patients Understand and Cope with BRCA Mutations
Sign Up to like & getrecommendations! Published in 2022 at "Current Oncology Reports"
DOI: 10.1007/s11912-022-01254-8
Abstract: Individuals carrying germline mutations in BRCA1/2 have unique psychosocial and educational needs that must be met to ensure informed clinical decision-making. In this review, we highlight the strategies used in clinical practice to support patients’… read more here.
Keywords: support; brca; helping patients; risk communication ... See more keywords
Platinum salts in the treatment of BRCA-associated breast cancer: A true targeted chemotherapy?
Sign Up to like & getrecommendations! Published in 2019 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2019.01.016
Abstract: Germline pathogenic mutations in breast cancer (BC) susceptibility genes (gBRCA1/2) are the most frequent inherited alterations in BC and are involved in the homologous recombination pathway, the principal mechanism of DNA double strand break repair.… read more here.
Keywords: platinum; platinum salts; breast cancer; brca ... See more keywords
Targeted surgical prevention of epithelial ovarian cancer is cost effective and saves money in BRCA mutation carrying family members of women with epithelial ovarian cancer. A Canadian model.
Sign Up to like & getrecommendations! Published in 2019 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2019.01.018
Abstract: OBJECTIVE Survival but not cure rates have improved for epithelial ovarian cancer (EOC), demonstrating the need for effective prevention. Targeted prevention in BRCA carriers by risk reducing surgery (RRS) prevents 80% of cases but incurs… read more here.
Keywords: epithelial ovarian; ovarian cancer; prevention; cost ... See more keywords
Germline BRCA mutation in male carriers—ripe for precision oncology?
Sign Up to like & getrecommendations! Published in 2017 at "Prostate Cancer and Prostatic Diseases"
DOI: 10.1038/s41391-017-0018-5
Abstract: BackgroundProstate cancer (PC) is one of the known heritable cancers with individual variations attributed to genetic factors. BRCA1 and BRCA2 are tumour suppressor genes with crucial roles in repairing DNA and thereby maintaining genomic integrity.… read more here.
Keywords: risk; germline brca; brca mutations; brca mutation ... See more keywords
Prediction of the functional impact of missense variants in BRCA1 and BRCA2 with BRCA-ML
Sign Up to like & getrecommendations! Published in 2020 at "NPJ Breast Cancer"
DOI: 10.1038/s41523-020-0159-x
Abstract: In silico predictions of missense variants is an important consideration when interpreting variants of uncertain significance (VUS) in the BRCA1 and BRCA2 genes. We trained and evaluated hundreds of machine learning algorithms based on results… read more here.
Keywords: prediction functional; functional impact; missense variants; brca1 brca2 ... See more keywords
H-Ferritin-nanocaged olaparib: a promising choice for both BRCA-mutated and sporadic triple negative breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07617-7
Abstract: Poly(ADP-ribose) polymerase (PARP) inhibitors represent a promising strategy toward the treatment of triple-negative breast cancer (TNBC), which is often associated to genomic instability and/or BRCA mutations. However, clinical outcome is controversial and no benefits have… read more here.
Keywords: negative breast; breast cancer; brca mutated; brca ... See more keywords
Genetic, clinic and histopathologic characterization of BRCA-associated hereditary breast and ovarian cancer in southwestern Finland.
Sign Up to like & getrecommendations! Published in 2022 at "Scientific reports"
DOI: 10.1038/s41598-022-10519-y
Abstract: We have analyzed the histopathological, clinical, and genetic characteristics in hereditary breast and ovarian cancer patients of counselled families from 1996 up to today in the southwestern Finland population. In this study we analyzed the… read more here.
Keywords: ovarian cancer; southwestern finland; cancer; brca ... See more keywords
Homologous repair deficiency-associated genes in invasive breast cancer revealed by WGCNA co-expression network analysis and genetic perturbation similarity analysis
Sign Up to like & getrecommendations! Published in 2023 at "Cell Cycle"
DOI: 10.1080/15384101.2023.2174339
Abstract: ABSTRACT Background: Homologous repair deficiency (HRD) causes double-strand break repair to be impeded, which is a common driver of carcinogenesis. However, the therapeutic and prognostic potential of HRD in invasive breast cancer (BRCA) has not… read more here.
Keywords: hrd; hrd score; analysis; gene ... See more keywords