Recapitulating the clinical scenario of BRCA‐associated pancreatic cancer in pre‐clinical models
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DOI: 10.1002/ijc.31292
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. BRCA‐associated PDAC comprises a clinically relevant subtype. A portion of these patients are highly susceptible to DNA damaging therapeutics, however, responses are heterogeneous and… read more here.
Keywords: brca associated; hrd genome; treatment;
Clinical characteristics and prognostic implications of BRCA-associated tumors in males: a pan-tumor survey
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DOI: 10.1186/s12885-020-07481-1
Abstract: Background The BRCA mutation (BRCAm) in males has been reported to confer a higher risk for the development of various tumors. However, little is known about its clinicopathologic features and prognostic implications. Design We conducted… read more here.
Keywords: tumor survey; associated tumors; pan tumor; prognostic implications ... See more keywords
Genetic, clinical and pathological characteristics of BRCA-associated breast cancer (BC) in Hispanic patients in the United States (US) and Latin America (LatAm).
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DOI: 10.1200/jco.2017.35.15_suppl.1539
Abstract: 1539Background: Hispanic women with BC present at a younger age, have a higher frequency of BRCA mutations and show a worse incidence-to-mortality ratio than non-Hispanic women. Information regarding the characteristics of BRCA-associated BC in Hispanics… read more here.
Keywords: hispanic patients; genetic clinical; characteristics brca; cancer ... See more keywords
A preclinical trial to evaluate therapies for BRCA-associated pancreatic cancer.
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DOI: 10.1200/jco.2017.35.4_suppl.332
Abstract: 332Background: Pancreatic ductal adenocarcinoma (PDAC) associated with germline BRCA1 or BRCA2mutations may have selective sensitivity to agents that exploit homologous recombination DNA repair defects. We hypothesized that cisplatin, a DNA-crosslinking agent, and talazoparib, a poly(ADP-ribose)… read more here.
Keywords: trial; trial evaluate; cisplatin; brca associated ... See more keywords