Recapitulating the clinical scenario of BRCA‐associated pancreatic cancer in pre‐clinical models
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DOI: 10.1002/ijc.31292
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. BRCA‐associated PDAC comprises a clinically relevant subtype. A portion of these patients are highly susceptible to DNA damaging therapeutics, however, responses are heterogeneous and… read more here.
Keywords: brca associated; hrd genome; treatment;
Abstract PO5-21-07: Mitomycin: its developmental role in the treatment of patients with BRCA - associated triple-negative early and locally advanced breast cancer
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DOI: 10.1158/1538-7445.sabcs23-po5-21-07
Abstract: Rationale. BRCA-associated triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with high sensitivity to chemotherapy, which leads to increased interest in the development of new strategies for neoadjuvant treatment… read more here.
Keywords: breast cancer; brca associated; triple negative; group ... See more keywords
Clinical characteristics and prognostic implications of BRCA-associated tumors in males: a pan-tumor survey
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DOI: 10.1186/s12885-020-07481-1
Abstract: Background The BRCA mutation (BRCAm) in males has been reported to confer a higher risk for the development of various tumors. However, little is known about its clinicopathologic features and prognostic implications. Design We conducted… read more here.
Keywords: tumor survey; associated tumors; pan tumor; prognostic implications ... See more keywords
Genetic, clinical and pathological characteristics of BRCA-associated breast cancer (BC) in Hispanic patients in the United States (US) and Latin America (LatAm).
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DOI: 10.1200/jco.2017.35.15_suppl.1539
Abstract: 1539Background: Hispanic women with BC present at a younger age, have a higher frequency of BRCA mutations and show a worse incidence-to-mortality ratio than non-Hispanic women. Information regarding the characteristics of BRCA-associated BC in Hispanics… read more here.
Keywords: hispanic patients; genetic clinical; characteristics brca; cancer ... See more keywords
A preclinical trial to evaluate therapies for BRCA-associated pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.4_suppl.332
Abstract: 332Background: Pancreatic ductal adenocarcinoma (PDAC) associated with germline BRCA1 or BRCA2mutations may have selective sensitivity to agents that exploit homologous recombination DNA repair defects. We hypothesized that cisplatin, a DNA-crosslinking agent, and talazoparib, a poly(ADP-ribose)… read more here.
Keywords: trial; trial evaluate; cisplatin; brca associated ... See more keywords