Proteomic signature for detection of high‐grade ovarian cancer in germline BRCA mutation carriers
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DOI: 10.1002/ijc.34318
Abstract: No current screening methods for high‐grade ovarian cancer (HGOC) guarantee effective early detection for high‐risk women such as germline BRCA mutation carriers. Therefore, the standard‐of‐care remains risk‐reducing salpingo‐oophorectomy (RRSO) around age 40. Proximal liquid biopsy… read more here.
Keywords: high grade; brca mutation; mutation carriers; mutation ... See more keywords
Genetic Diagnosis before Surgery has an Impact on Surgical Decision in BRCA Mutation Carriers with Breast Cancer
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DOI: 10.1007/s00268-017-4342-7
Abstract: BackgroundThe first aim of our study was to evaluate surgical decision-making by BRCA mutation carriers with breast cancer based on the timing of knowledge of their BRCA mutation status. The second aim was to evaluate… read more here.
Keywords: cancer; surgery; brca mutation; breast cancer ... See more keywords
Effect of risk-reducing salpingo-oophorectomy on quality of life in Korean BRCA mutation carriers.
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DOI: 10.1016/j.asjsur.2021.01.007
Abstract: BACKGROUND This study aimed to compare the quality of life (QOL), psychosocial status, sexual function, and menopausal symptoms between the risk-reducing salpingo-oophorectomy (RRSO) and non-RRSO groups comprising BRCA mutation carriers and to evaluate the effect… read more here.
Keywords: mutation carriers; rrso group; brca mutation; rrso ... See more keywords
Germline BRCA mutation in male carriers—ripe for precision oncology?
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DOI: 10.1038/s41391-017-0018-5
Abstract: BackgroundProstate cancer (PC) is one of the known heritable cancers with individual variations attributed to genetic factors. BRCA1 and BRCA2 are tumour suppressor genes with crucial roles in repairing DNA and thereby maintaining genomic integrity.… read more here.
Keywords: risk; germline brca; brca mutations; brca mutation ... See more keywords
Evaluating BRCA mutation risk predictive models in a Chinese cohort in Taiwan
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DOI: 10.1038/s41598-019-46707-6
Abstract: Accurate estimation of carrier probabilities of cancer susceptibility gene mutations is an important part of pre-test genetic counselling. Many predictive models are available but their applicability in the Asian population is uncertain. We evaluated the… read more here.
Keywords: breast; brca mutation; history; predictive models ... See more keywords
Misdiagnosis of High-grade Serous Ovarian Cancer With BRCA Mutation as Endometriotic Cyst Due to Its Unique Gross Morphology: A Case Report and Literature Review.
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Gynecological Pathology"
DOI: 10.1097/pgp.0000000000000663
Abstract: It is believed that high-grade serous ovarian cancer (HGSOC) is a solid or multilocular-solid cancer. Here, we report the case of a 40-yr-old woman with a left ovarian unilocular cyst. Ultrasonography and computed tomographic examination… read more here.
Keywords: high grade; case; cancer; cyst ... See more keywords
Should we or should we not? Risk reduction bilateral salpingectomy for BRCA mutation carriers
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2021-002682
Abstract: Dear Editor, We read with great interest the recent article by Corrado et al, but would like to comment on a particular issue of concern. The authors state: “women may choose surgical options, such as… read more here.
Keywords: risk; mutation carriers; brca mutation; salpingectomy ... See more keywords
Response to: Should we or should we not? Risk reduction bilateral salpingectomy for BRCA mutation carriers
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2021-002738
Abstract: The standard recommended risk reducing procedure for BRCA 1 or 2 mutation carriers remains prophylactic salpingooophorectomy, tailored to the type of BRCA mutation and the patient’s age. Nonetheless, it should also be underlined that, despite… read more here.
Keywords: risk; mutation carriers; brca mutation; cancer ... See more keywords
FDA Approval Summary: Rucaparib for the Treatment of Patients with Deleterious BRCA Mutation–Associated Advanced Ovarian Cancer
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DOI: 10.1158/1078-0432.ccr-17-1337
Abstract: On December 19, 2016, the FDA granted accelerated approval to rucaparib (RUBRACA; Clovis Oncology, Inc.) for the treatment of patients with deleterious BRCA mutation (germline and/or somatic)–associated advanced ovarian cancer who have been treated with… read more here.
Keywords: treatment; brca mutation; rucaparib; ovarian cancer ... See more keywords
Abstract 4283: BRCA1 and BRCA 2 mutation predictions using BRACAPRO and MYRIAD models in patients with Korean ethnicity
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DOI: 10.1158/1538-7445.am2017-4283
Abstract: Introduction: This study is aimed to compare the predictive efficacy of BRCAPRO and MYRIAD BRCA risk calculator in patients tested in Korean ethnicity. Methods: Individuals, who received gene test on BRCA mutation from November 2010… read more here.
Keywords: brca mutation; cancer; korean ethnicity; brca ... See more keywords
Abstract 4438: Role of USP1 in overcoming chemoresistance Independent of BRCA mutation status
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DOI: 10.1158/1538-7445.am2025-4438
Abstract: The efficacy of chemotherapeutic agents like Cisplatin is often limited by DNA repair mechanisms, including the PARP and USP1, that regulates DNA damage response proteins. In this study, we explore the effects of USP1 inhibition,… read more here.
Keywords: brca mutation; mutation status; cell;