Poly (ADP-ribose) Polymerase Inhibition in Patients with Breast Cancer and BRCA 1 and 2 Mutations
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DOI: 10.1007/s40265-019-01235-5
Abstract: The poly-(ADP-ribose) polymerase (PARP) inhibitors olaparib and talazoparib, have recently been approved for use in patients with metastatic breast cancer (BC) and germline BRCA 1 or 2 mutations due to improved progression-free survival compared to… read more here.
Keywords: poly adp; brca mutations; breast cancer; ribose polymerase ... See more keywords
Risk of cardiovascular disease among women carrying BRCA mutations after risk-reducing bilateral salpingo-oophorectomy: A population-based study.
Sign Up to like & getrecommendations! Published in 2021 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2021.06.022
Abstract: OBJECTIVE Examine the risk of cardiovascular disease (CVD) following risk reducing bilateral salpingo-oophorectomy (RRBSO) among women with BRCA mutations. METHODS In this retrospective population-based study in British Columbia, Canada, between 1996 and 2017, we compared… read more here.
Keywords: women brca; risk; brca mutations; disease ... See more keywords
Germline BRCA mutation in male carriers—ripe for precision oncology?
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DOI: 10.1038/s41391-017-0018-5
Abstract: BackgroundProstate cancer (PC) is one of the known heritable cancers with individual variations attributed to genetic factors. BRCA1 and BRCA2 are tumour suppressor genes with crucial roles in repairing DNA and thereby maintaining genomic integrity.… read more here.
Keywords: risk; germline brca; brca mutations; brca mutation ... See more keywords
Prevalence and Clinical Characterization of BRCA1 and BRCA2 Mutations in Korean Patients with Epithelial Ovarian Cancer.
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DOI: 10.1111/cas.15166
Abstract: This study was performed to investigate the prevalence, clinical characteristics and treatment response according to BRCA1 and BRCA2 (BRCA) mutations in Korean patients with epithelial ovarian cancer (EOC). Two-hundred ninety-eight Korean women diagnosed with high-grade… read more here.
Keywords: mutations korean; brca mutations; prevalence; korean patients ... See more keywords
Mucinous Histology, BRCA1/2 Mutations, and Elevated Tumor Mutational Burden in Colorectal Cancer
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DOI: 10.1155/2020/6421205
Abstract: Mucinous colorectal carcinomas (MC) constitute 10% of colorectal malignancies. Recently, an increased risk of colorectal cancer has been demonstrated in germline BRCA1/2 mutation carriers. Furthermore, BRCA1/2 germline mutation carriers have exhibited a higher-than-expected frequency of… read more here.
Keywords: tumor mutational; brca mutations; colorectal cancer; mucinous histology ... See more keywords
BRCA mutations in a cohort of Iraqi patients presenting to a tertiary referral center
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DOI: 10.1186/s12881-019-0885-9
Abstract: BackgroundUnique pathogenic mutations in BRCA1 and 2 genes have been reported in different populations of patients originating from the Middle East region. Limited data are available for the Iraqi population. For many reasons a large… read more here.
Keywords: cohort iraqi; iraqi patients; patients presenting; brca mutations ... See more keywords
Predictive factors for prolonged response to olaparib as maintenance therapy in ovarian cancer patients with BRCA mutations.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.5558
Abstract: 5558Background: To investigate clinical factors predictive for prolonged progression-free survival (PFS) in ovarian cancer (OC) patients carrying BRCA mutations and receiving olaparib as a maintena... read more here.
Keywords: predictive factors; brca mutations; ovarian cancer; cancer patients ... See more keywords
BRCA 1/2 mutations in high-grade serous ovarian cancer (HGS-OC) patients of three Latin American countries: Report of 412 cases.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e14288
Abstract: e14288 Background: Ovarian Cancer (OC) is the most common gynecologic cancer in women in the World and with elevated mortality. High Grade Serous Ovarian Cancer (HGS-OC) is a common histotype and closely related with the… read more here.
Keywords: high grade; latin american; ovarian cancer; brca mutations ... See more keywords
BRCA mutations in metastatic colorectal cancer (mCRC) and response to chemotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.4_suppl.235
Abstract: 235Background: Mutations in BRCA 1/2 are typically associated with breast, ovarian, pancreatic and prostate cancers. BRCA mutations have been reported in colorectal cancer in sporadic case series. ... read more here.
Keywords: cancer mcrc; metastatic colorectal; mutations metastatic; colorectal cancer ... See more keywords
BRCA mutations in the manifestation and treatment of ovarian cancer
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DOI: 10.18632/oncotarget.18280
Abstract: BRCA genes are important for the integrity and stability of genetic material and play key roles in repairing DNA breaks via high fidelity homologous recombination. BRCA mutations are known to predispose carriers to gynecological malignancies,… read more here.
Keywords: treatment; brca mutations; manifestation treatment; mutations manifestation ... See more keywords
Role of BRCA Mutations in the Modulation of Response to Platinum Therapy
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DOI: 10.3389/fonc.2018.00016
Abstract: Recent years have seen cancer emerge as one of the leading cause of mortality worldwide with breast cancer being the second most common cause of death among women. Individuals harboring BRCA mutations are at a… read more here.
Keywords: platinum therapy; brca mutations; role; response ... See more keywords