Poly (ADP-ribose) Polymerase Inhibition in Patients with Breast Cancer and BRCA 1 and 2 Mutations
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DOI: 10.1007/s40265-019-01235-5
Abstract: The poly-(ADP-ribose) polymerase (PARP) inhibitors olaparib and talazoparib, have recently been approved for use in patients with metastatic breast cancer (BC) and germline BRCA 1 or 2 mutations due to improved progression-free survival compared to… read more here.
Keywords: poly adp; brca mutations; breast cancer; ribose polymerase ... See more keywords
Risk of cardiovascular disease among women carrying BRCA mutations after risk-reducing bilateral salpingo-oophorectomy: A population-based study.
Sign Up to like & getrecommendations! Published in 2021 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2021.06.022
Abstract: OBJECTIVE Examine the risk of cardiovascular disease (CVD) following risk reducing bilateral salpingo-oophorectomy (RRBSO) among women with BRCA mutations. METHODS In this retrospective population-based study in British Columbia, Canada, between 1996 and 2017, we compared… read more here.
Keywords: women brca; risk; brca mutations; disease ... See more keywords
BRCA Mutations and MicroRNA Expression Patterns in the Peripheral Blood of Breast Cancer Patients
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DOI: 10.1021/acsomega.3c10086
Abstract: Breast cancer (BC) persists as the predominant malignancy globally, standing as the foremost cause of cancer-related mortality among women. Despite notable advancements in prevention and treatment, encompassing the incorporation of targeted immunotherapies, a continued imperative… read more here.
Keywords: expression; breast cancer; brca mutations; mutations microrna ... See more keywords
Germline BRCA mutation in male carriers—ripe for precision oncology?
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DOI: 10.1038/s41391-017-0018-5
Abstract: BackgroundProstate cancer (PC) is one of the known heritable cancers with individual variations attributed to genetic factors. BRCA1 and BRCA2 are tumour suppressor genes with crucial roles in repairing DNA and thereby maintaining genomic integrity.… read more here.
Keywords: risk; germline brca; brca mutations; brca mutation ... See more keywords
Prevalence and Clinical Characterization of BRCA1 and BRCA2 Mutations in Korean Patients with Epithelial Ovarian Cancer.
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DOI: 10.1111/cas.15166
Abstract: This study was performed to investigate the prevalence, clinical characteristics and treatment response according to BRCA1 and BRCA2 (BRCA) mutations in Korean patients with epithelial ovarian cancer (EOC). Two-hundred ninety-eight Korean women diagnosed with high-grade… read more here.
Keywords: mutations korean; brca mutations; prevalence; korean patients ... See more keywords
Mucinous Histology, BRCA1/2 Mutations, and Elevated Tumor Mutational Burden in Colorectal Cancer
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DOI: 10.1155/2020/6421205
Abstract: Mucinous colorectal carcinomas (MC) constitute 10% of colorectal malignancies. Recently, an increased risk of colorectal cancer has been demonstrated in germline BRCA1/2 mutation carriers. Furthermore, BRCA1/2 germline mutation carriers have exhibited a higher-than-expected frequency of… read more here.
Keywords: tumor mutational; brca mutations; colorectal cancer; mucinous histology ... See more keywords
Abstract PO5-17-06: Prevalence of BRCA Mutations: A Predictive Model in a High-Risk Population of BC Patients at a Tertiary Care Center
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DOI: 10.1158/1538-7445.sabcs23-po5-17-06
Abstract: Background: Breast cancer (BC) is a prevalent cancer in Saudi Arabia, with the majority of cases being sporadic. However, 25-30% of cases are associated with hereditary factors. Germline BRCA mutations are the most common mutations… read more here.
Keywords: history; brca; brca mutations; risk ... See more keywords
BRCA mutations in a cohort of Iraqi patients presenting to a tertiary referral center
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DOI: 10.1186/s12881-019-0885-9
Abstract: BackgroundUnique pathogenic mutations in BRCA1 and 2 genes have been reported in different populations of patients originating from the Middle East region. Limited data are available for the Iraqi population. For many reasons a large… read more here.
Keywords: cohort iraqi; iraqi patients; patients presenting; brca mutations ... See more keywords
Predictive factors for prolonged response to olaparib as maintenance therapy in ovarian cancer patients with BRCA mutations.
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DOI: 10.1200/jco.2018.36.15_suppl.5558
Abstract: 5558Background: To investigate clinical factors predictive for prolonged progression-free survival (PFS) in ovarian cancer (OC) patients carrying BRCA mutations and receiving olaparib as a maintena... read more here.
Keywords: predictive factors; brca mutations; ovarian cancer; cancer patients ... See more keywords
BRCA 1/2 mutations in high-grade serous ovarian cancer (HGS-OC) patients of three Latin American countries: Report of 412 cases.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e14288
Abstract: e14288 Background: Ovarian Cancer (OC) is the most common gynecologic cancer in women in the World and with elevated mortality. High Grade Serous Ovarian Cancer (HGS-OC) is a common histotype and closely related with the… read more here.
Keywords: high grade; latin american; ovarian cancer; brca mutations ... See more keywords
BRCA mutations in metastatic colorectal cancer (mCRC) and response to chemotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.4_suppl.235
Abstract: 235Background: Mutations in BRCA 1/2 are typically associated with breast, ovarian, pancreatic and prostate cancers. BRCA mutations have been reported in colorectal cancer in sporadic case series. ... read more here.
Keywords: cancer mcrc; metastatic colorectal; mutations metastatic; colorectal cancer ... See more keywords