The risks of cancer in older women with BRCA pathogenic variants: How far have we come?
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34615
Abstract: The purpose of this study was to estimate the cumulative risks of all cancers in women from 50 to 75 years of age with a BRCA1 or BRCA2 pathogenic variant. read more here.
Keywords: risks cancer; women brca; older women; brca pathogenic ... See more keywords
Influence of BRCA pathogenic variants in the benefit of secondary cytoreductive surgery.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.6076
Abstract: 6076Background: Germline BRCA pathogenic variants are present in 15% to 25% of ovarian carcinoma patients. These tumors are more sensitive to platinum and PARP inhibitor therapy and have a better p... read more here.
Keywords: pathogenic variants; variants benefit; benefit secondary; influence brca ... See more keywords
Should Preimplantation Genetic Testing (PGT) Systematically Be Proposed to BRCA Pathogenic Variant Carriers?
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14235769
Abstract: Simple Summary Preimplantation genetic testing (PGT) has been developed to avoid the transmission of a critical hereditary disease, by selecting embryos for uterine transfer using a genetic analysis. BRCA mutated patients can undergo PGT and… read more here.
Keywords: preimplantation genetic; pgt; genetic testing; brca pathogenic ... See more keywords
Impact of Breast Cancer and Germline BRCA Pathogenic Variants on Fertility Preservation in Young Women
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13040930
Abstract: Background: Several studies have suggested that breast cancer (BC) and germline BRCA pathogenic variants (gBRCA PVs) could have a deleterious impact on ovarian reserve. Nevertheless, data are limited and mixed. Our objective was to evaluate… read more here.
Keywords: pathogenic variants; germline brca; cancer germline; breast cancer ... See more keywords