The FANC/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-Links
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DOI: 10.3390/genes11050585
Abstract: DNA interstrand cross-links (ICLs) represent a major barrier blocking DNA replication fork progression. ICL accumulation results in growth arrest and cell death—particularly in cell populations undergoing high replicative activity, such as cancer and leukemic cells.… read more here.
Keywords: dna interstrand; dna; fanc brca; interstrand cross ... See more keywords