The role of BRCA1‐associated protein 1 in the diagnosis of malignant mesothelioma in effusion and fine‐needle aspiration cytology
Sign Up to like & getrecommendations! Published in 2019 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.24061
Abstract: Malignant mesothelioma (MM) is a diagnostically challenging entity in cytology specimens due to the lack of architectural context and a cytomorphologic overlap between malignant and reactive mesothelial cells (RMCs). A diagnostic marker with excellent specificity… read more here.
Keywords: associated protein; cytology; brca1 associated; malignant mesothelioma ... See more keywords
Up-regulation of BRCA1-associated RING Domain 1 Promotes Hepatocellular Carcinoma Progression by Targeting Akt Signaling
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DOI: 10.1038/s41598-017-07962-7
Abstract: The present study was designed to investigate the potential clinical, pathological, prognostic value, role and mechanism of BRCA1-associated RING Domain 1 (BARD1) in Hepatocellular carcinoma (HCC). Quantitative real-time PCR and immunohistochemistry were performed to evaluate… read more here.
Keywords: associated ring; hcc; bard1; ring domain ... See more keywords
BRCA1-Associated Protein-1 Suppresses Osteosarcoma Cell Proliferation and Migration Through Regulation PI3K/Akt Pathway.
Sign Up to like & getrecommendations! Published in 2017 at "DNA and cell biology"
DOI: 10.1089/dna.2016.3579
Abstract: BRCA1-associated protein-1 (BAP1) is an important nuclear-localized deubiquitinating enzyme. Dysregulation of BAP1 has been reported in many types of cancers. However, there are few articles on the role of BAP1 in osteosarcoma (OS) and the… read more here.
Keywords: associated protein; cell proliferation; bap1; pi3k akt ... See more keywords
BRCA1-associated R-loop affects transcription and differentiation in breast luminal epithelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz262
Abstract: Abstract BRCA1-associated basal-like breast cancer originates from luminal progenitor cells. Breast epithelial cells from cancer-free BRCA1 mutation carriers are defective in luminal differentiation. However, how BRCA1 deficiency leads to lineage-specific differentiation defect is not clear.… read more here.
Keywords: transcription; epithelial cells; brca1; differentiation ... See more keywords
Abstract A61: BRCA1-associated R-loop accumulation at noncoding putative ERα enhancer area blocks luminal epithelial differentiation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.advbc17-a61
Abstract: Most BRCA1 -associated breast tumors are basal-like, yet originate from luminal progenitor cells. BRCA1 is best known for its functions in double-strand break (DSB) repair and resolution of DNA replication stress. However, it is unclear… read more here.
Keywords: accumulation; brca1; enhancer area; loop accumulation ... See more keywords
Phase II trial of the PARP inhibitor, niraparib, in BRCA1-Associated Protein 1 (BAP1) and other DNA damage response (DDR) pathway deficient neoplasms including cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.3_suppl.tps354
Abstract: TPS354Background: BRCA1-Associated Protein 1 (BAP1) is a critical regulator of the cell cycle, cellular differentiation, cell death, and DNA damage response. It also acts as a tumor suppressor. Pre... read more here.
Keywords: protein bap1; associated protein; damage response; brca1 associated ... See more keywords
Role of BRCA1-associated protein (BRAP) variant in childhood pulmonary arterial hypertension
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DOI: 10.1371/journal.pone.0211450
Abstract: Although mutations in several genes have been reported in pulmonary arterial hypertension (PAH), most of PAH cases do not carry these mutations. This study aimed to identify a novel cause of PAH. To determine the… read more here.
Keywords: associated protein; protein brap; arterial hypertension; brap ... See more keywords
Progression-free survival and overall survival after BRCA1/2-associated epithelial ovarian cancer: A matched cohort study
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DOI: 10.1371/journal.pone.0275015
Abstract: Introduction Germline BRCA1/2-associated epithelial ovarian cancer has been associated with better progression-free survival and overall survival than sporadic epithelial ovarian cancer, but conclusive data are lacking. Methods We matched 389 BRCA1-associated and 123 BRCA2-associated epithelial… read more here.
Keywords: brca1 associated; epithelial ovarian; survival; ovarian cancer ... See more keywords