Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3091
Abstract: The tumor‐suppressor protein BRCA1 works with BARD1 to catalyze the transfer of ubiquitin onto protein substrates. The N‐terminal regions of BRCA1 and BARD1 that contain their RING domains are responsible for dimerization and ubiquitin ligase… read more here.
Keywords: ubiquitin ligase; activity; brca1 bard1;
SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108921
Abstract: SUMMARY The breast cancer type I susceptibility protein (BRCA1) and BRCA1-associated RING domain protein I (BARD1) heterodimer promote genome integrity through pleiotropic functions, including DNA double-strand break (DSB) repair by homologous recombination (HR). BRCA1-BARD1 heterodimerization… read more here.
Keywords: bard1 heterodimerization; brca1 bard1; sirt2;
The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-020-0218-z
Abstract: The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA double-strand break (DSB) repair by homologous recombination and protects DNA replication forks from attrition. BRCA1 partners with BRCA1-associated RING domain protein 1 (BARD1)… read more here.
Keywords: dna repair; repair replication; replication; brca1 bard1 ... See more keywords
Preferential Involvement of BRCA1/BARD1, Not Tip60/Fe65, in DNA Double-Strand Break Repair in Presenilin-1 P117L Alzheimer Models
Sign Up to like & getrecommendations! Published in 2022 at "Neural Plasticity"
DOI: 10.1155/2022/3172861
Abstract: Recently, we showed that DNA double-strand breaks (DSBs) are increased by the Aβ42-amyloid peptide and decreased by all-trans retinoic acid (RA) in SH-SY5Y cells and C57BL/6J mice. The present work was aimed at investigating DSBs… read more here.
Keywords: dna double; p117l; double strand; brca1 bard1 ... See more keywords
Differential requirement for BRCA1-BARD1 E3 ubiquitin ligase activity in DNA damage repair and meiosis in the Caenorhabditis elegans germ line
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010457
Abstract: The tumor suppressor BRCA1-BARD1 complex functions in many cellular processes; of critical importance to its tumor suppressor function is its role in genome integrity. Although RING E3 ubiquitin ligase activity is the only known enzymatic… read more here.
Keywords: dna damage; ligase activity; activity; brca1 bard1 ... See more keywords
CRL4-DCAF8L1 Regulates BRCA1 and BARD1 Protein Stability
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.57178
Abstract: BRCA1 is frequently down-regulated in breast cancer, the underlying mechanism is unclear. Here we identified DCAF8L1, an X-linked gene product, as a DDB1-Cullin associated Factor (DCAF) for CUL4 E3 ligases to target BRCA1 and BARD1… read more here.
Keywords: stability; breast cancer; dcaf8l1; brca1 bard1 ... See more keywords