Altered expression of telomere‐associated genes in leukocytes among BRCA1 and BRCA2 carriers
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DOI: 10.1002/mc.22773
Abstract: Telomere dysfunction resulting from telomere shortening and deregulation of shelterin components has been linked to the pathogenesis of age‐related disorders, including cancer. Recent evidence suggests that BRCA1/2 (BRCA1 and BRCA2) tumor suppressor gene products play… read more here.
Keywords: brca1 brca2; brca1 carriers; expression telomere; telomere associated ... See more keywords
Cancer worry among BRCA1/2 pathogenic variant carriers choosing surgery to prevent tubal/ovarian cancer: course over time and associated factors
Sign Up to like & getrecommendations! Published in 2022 at "Supportive Care in Cancer"
DOI: 10.1007/s00520-021-06726-4
Abstract: High cancer risks, as applicable to BRCA1 and BRCA2 pathogenic variant (PV) carriers, can induce significant cancer concerns. We examined the degree of cancer worry and the course of this worry among BRCA1/2-PV carriers undergoing… read more here.
Keywords: cancer; brca1 carriers; cancer worry; surgery ... See more keywords
Phase II trial of veliparib and temozolomide in metastatic breast cancer patients with and without BRCA1/2 mutations
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DOI: 10.1007/s10549-021-06292-7
Abstract: We evaluated the efficacy and safety of poly-(adenosine diphosphate-ribose) polymerase (PARP) 1 and 2 inhibitor veliparib and temozolomide in metastatic breast cancer patients with and without germline BRCA1/2 mutations. In this single-arm phase II trial,… read more here.
Keywords: breast; breast cancer; metastatic breast; veliparib temozolomide ... See more keywords
Contraceptives and cancer risks in BRCA1/2 pathogenic variant carriers: a systematic review and meta-analysis
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DOI: 10.1093/humupd/dmac038
Abstract: Abstract BACKGROUND Increasing numbers of BReast CAncer (BRCA) 1 or 2 pathogenic variant (PV) carriers, who have an inherited predisposition to breast and ovarian cancer, are being identified. Among these women, data regarding the effects… read more here.
Keywords: brca1 carriers; ovarian cancer; breast cancer; risk ... See more keywords
Mifepristone mediates anti‐proliferative effect on ovarian mesenchymal stem/stromal cells from female BRCA1−/2− carriers
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DOI: 10.1111/aogs.13485
Abstract: Women with hereditary mutation in breast cancer‐associated genes (BRCA1−/2−) have a higher lifetime risk of developing ovarian cancer. Here, we aimed to investigate the effect of mifepristone, a selective progesterone receptor modulator of ovarian mesenchymal… read more here.
Keywords: stem stromal; stromal cells; effect; ovarian mesenchymal ... See more keywords
Gastric Cancer Risk and Pathogenesis in BRCA1 and BRCA2 Carriers
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DOI: 10.3390/cancers14235953
Abstract: Simple Summary Germline BRCA1 and BRCA2 pathogenic variant carriers are recognized to be at increased risk for multiple cancers including breast, ovarian, pancreatic, and prostate cancer, with risk management recommendations for these cancers included in… read more here.
Keywords: brca1; brca1 carriers; risk; cancer risk ... See more keywords