Altered expression of telomere‐associated genes in leukocytes among BRCA1 and BRCA2 carriers
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22773
Abstract: Telomere dysfunction resulting from telomere shortening and deregulation of shelterin components has been linked to the pathogenesis of age‐related disorders, including cancer. Recent evidence suggests that BRCA1/2 (BRCA1 and BRCA2) tumor suppressor gene products play… read more here.
Keywords: brca1 brca2; brca1 carriers; expression telomere; telomere associated ... See more keywords
Cancer worry among BRCA1/2 pathogenic variant carriers choosing surgery to prevent tubal/ovarian cancer: course over time and associated factors
Sign Up to like & getrecommendations! Published in 2022 at "Supportive Care in Cancer"
DOI: 10.1007/s00520-021-06726-4
Abstract: High cancer risks, as applicable to BRCA1 and BRCA2 pathogenic variant (PV) carriers, can induce significant cancer concerns. We examined the degree of cancer worry and the course of this worry among BRCA1/2-PV carriers undergoing… read more here.
Keywords: cancer; brca1 carriers; cancer worry; surgery ... See more keywords
Phase II trial of veliparib and temozolomide in metastatic breast cancer patients with and without BRCA1/2 mutations
Sign Up to like & getrecommendations! Published in 2021 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-021-06292-7
Abstract: We evaluated the efficacy and safety of poly-(adenosine diphosphate-ribose) polymerase (PARP) 1 and 2 inhibitor veliparib and temozolomide in metastatic breast cancer patients with and without germline BRCA1/2 mutations. In this single-arm phase II trial,… read more here.
Keywords: breast; breast cancer; metastatic breast; veliparib temozolomide ... See more keywords
Contraceptives and cancer risks in BRCA1/2 pathogenic variant carriers: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Human Reproduction Update"
DOI: 10.1093/humupd/dmac038
Abstract: Abstract BACKGROUND Increasing numbers of BReast CAncer (BRCA) 1 or 2 pathogenic variant (PV) carriers, who have an inherited predisposition to breast and ovarian cancer, are being identified. Among these women, data regarding the effects… read more here.
Keywords: brca1 carriers; ovarian cancer; breast cancer; risk ... See more keywords
Mifepristone mediates anti‐proliferative effect on ovarian mesenchymal stem/stromal cells from female BRCA1−/2− carriers
Sign Up to like & getrecommendations! Published in 2019 at "Acta Obstetricia et Gynecologica Scandinavica"
DOI: 10.1111/aogs.13485
Abstract: Women with hereditary mutation in breast cancer‐associated genes (BRCA1−/2−) have a higher lifetime risk of developing ovarian cancer. Here, we aimed to investigate the effect of mifepristone, a selective progesterone receptor modulator of ovarian mesenchymal… read more here.
Keywords: stem stromal; stromal cells; effect; ovarian mesenchymal ... See more keywords
Abstract P2-11-10: Assessing the Differential Response to Immunotherapy in BRCA1/2 Mutation Carriers with Triple-Negative Breast Cancer
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.sabcs24-p2-11-10
Abstract: Background: The addition of pembrolizumab to standard neoadjuvant chemotherapy (NAC+P) for patients with triple-negative breast cancer (TNBC) has been shown to result in higher rates of pathologic complete response (pCR) and longer event-free survival compared… read more here.
Keywords: breast cancer; brca1; response; brca1 carriers ... See more keywords
Gastric Cancer Risk and Pathogenesis in BRCA1 and BRCA2 Carriers
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DOI: 10.3390/cancers14235953
Abstract: Simple Summary Germline BRCA1 and BRCA2 pathogenic variant carriers are recognized to be at increased risk for multiple cancers including breast, ovarian, pancreatic, and prostate cancer, with risk management recommendations for these cancers included in… read more here.
Keywords: brca1; brca1 carriers; risk; cancer risk ... See more keywords
Blood Lead Level as Marker of Increased Risk of Ovarian Cancer in BRCA1 Carriers
Sign Up to like & getrecommendations! Published in 2024 at "Nutrients"
DOI: 10.3390/nu16091370
Abstract: BRCA1 mutations substantially elevate the risks of breast and ovarian cancer. Various modifiers, including environmental factors, can influence cancer risk. Lead, a known carcinogen, has been associated with various cancers, but its impact on BRCA1… read more here.
Keywords: cancer; risk; ovarian cancer; brca1 carriers ... See more keywords
Blood Iodine as a Potential Marker of the Risk of Cancer in BRCA1 Carriers
Sign Up to like & getrecommendations! Published in 2024 at "Nutrients"
DOI: 10.3390/nu16111788
Abstract: Breast cancer and ovarian cancer pose a significant risk for BRCA1 carriers, with limited risk-reduction strategies. While improved screening helps in the early detection of breast cancer, preventive measures remain elusive. Emerging evidence suggests a… read more here.
Keywords: cancer risk; cancer; iodine; risk ... See more keywords