BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020)
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Science"
DOI: 10.1002/advs.202070033
Abstract: Mitophagy is a selective autophagic process for clearing damaged mitochondria and maintaining a healthy mitochondrial network. In article number https://doi.org/10.1002/advs.201903616, Qiang Chen, Chu‐Xia Deng, and co‐workers demonstrate breast cancer susceptibility gene 1 (BRCA1) facilitates mitophagy… read more here.
Keywords: inflammasome activation; brca1; mammary tumor; tumor metastasis ... See more keywords
G-Quadruplex Matters in Tissue-Specific Tumorigenesis by BRCA1 Deficiency
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13030391
Abstract: How and why distinct genetic alterations, such as BRCA1 mutation, promote tumorigenesis in certain tissues, but not others, remain an important issue in cancer research. The underlying mechanisms may reveal tissue-specific therapeutic vulnerabilities. Although the… read more here.
Keywords: brca1; brca1 deficiency; tumorigenesis brca1; tumorigenesis ... See more keywords