Genetic polymorphisms and haplotypes of BRCA1 gene associated with quality of life and survival among patients with non-small-cell lung cancer
Sign Up to like & getrecommendations! Published in 2020 at "Quality of Life Research"
DOI: 10.1007/s11136-020-02509-2
Abstract: Quality of life (QoL) and prognosis of lung cancer (LC) patients are poor. Previous studies focused less on the relationship between genetic factors and the QoL of LC patients. The current study is intended to… read more here.
Keywords: haplotypes brca1; brca1 gene; lung cancer; quality life ... See more keywords
Feasibility of targeted cascade genetic testing in the family members of BRCA1/2 gene pathogenic variant/likely pathogenic variant carriers
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DOI: 10.1038/s41598-022-05931-3
Abstract: The pathogenic variant (PV) or likely pathogenic variant (LPV) BRCA1/2 gene is strongly associated with hereditary breast or ovarian cancer. Therefore, it is important to screen blood relatives to establish preventive modalities and surveillance. This… read more here.
Keywords: family members; brca1 gene; gene; pathogenic variant ... See more keywords
Comparison of genetic diversity and phylogenetic structure of BRCA1 gene of some domestic and wild sheep breeds in different countries.
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DOI: 10.1080/10495398.2023.2187410
Abstract: BRCA1 gene plays an important role in DNA damage repair, cell cycle, and transcription process regulation; hence it's called gate keeper. The current research aims to perform bioinformatics analyzes of the BRCA1 gene of different… read more here.
Keywords: domestic wild; diversity; brca1 gene; sheep breeds ... See more keywords
Identification of Germinal Mutations in Eight Exons of the BRCA1 Gene in Breast Cancer Patients in the State of Amazonas, Using Direct Sequencing
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DOI: 10.17265/2328-2150/2020.11.005
Abstract: Mutations in the BRCA1 gene are responsible for 50% of cases of hereditary breast cancer. The objective of this study was to perform screening of mutations in the BRCA1 gene in breast cancer patients treated… read more here.
Keywords: breast cancer; state amazonas; brca1 gene; gene ... See more keywords
Mutations in exon 11 (11.1 and 11.2) of the BRCA1 gene and risk factors for breast cancer in Burkina Faso
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DOI: 10.4081/jphia.2022.1921
Abstract: Breast cancer is the leading cause of death among women in both developed and developing countries. It is multifactorial, including genetic predispositions such as oncogenic mutations on BRCA1 and 2 genes. The objectives of the… read more here.
Keywords: mutations exon; breast cancer; risk factors; brca1 gene ... See more keywords
Evaluation of promoter hypermethylation of tumor suppressor gene BRCA1 in epithelial ovarian cancer
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DOI: 10.4103/jcrt.jcrt_390_20
Abstract: Context: Epithelial ovarian cancer (EOC) is a serious gynecological issue worldwide and its late detection is the major encumbrance in treatment procedures. Hypermethylation-mediated BRCA1 gene silencing results in failure of the repair system of damaged… read more here.
Keywords: epithelial ovarian; promoter hypermethylation; brca1 gene; gene ... See more keywords