BRCA1 promoter methylation and clinical outcomes in ovarian cancer: an individual patient data meta-analysis.
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DOI: 10.1093/jnci/djaa070
Abstract: BACKGROUND BRCA1 methylation has been associated with homologous recombination deficiency, a biomarker of platinum sensitivity. Studies evaluating BRCA1-methylated tubal/ovarian cancer (OC) do not consistently support improved survival following platinum chemotherapy. We examine the characteristics of… read more here.
Keywords: methylation; brca1; brca1 methylation; cancer ... See more keywords