BRCA1 promoter methylation and clinical outcomes in ovarian cancer: an individual patient data meta-analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the National Cancer Institute"
DOI: 10.1093/jnci/djaa070
Abstract: BACKGROUND BRCA1 methylation has been associated with homologous recombination deficiency, a biomarker of platinum sensitivity. Studies evaluating BRCA1-methylated tubal/ovarian cancer (OC) do not consistently support improved survival following platinum chemotherapy. We examine the characteristics of… read more here.
Keywords: methylation; brca1; brca1 methylation; cancer ... See more keywords
BRCA1 methylation in newborns: genetic disposition, maternal transfer, environmental influence, or by chance only?
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DOI: 10.1186/s13148-018-0566-0
Abstract: In this letter, we respond to and discuss the recent publication by Al-Moghrabi et al.: Methylation of BRCA1 and MGMT genes in white blood cells are transmitted from mothers to daughters. We discuss their findings… read more here.
Keywords: methylation; newborns genetic; brca1 methylation; genetic disposition ... See more keywords
MicroRNA-155-5p, Reduced by Curcumin-Re-Expressed Hypermethylated BRCA1, Is a Molecular Biomarker for Cancer Risk in BRCA1-methylation Carriers
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DOI: 10.3390/ijms24109021
Abstract: Constitutional BRCA1-methylation is a cancer risk factor for breast (BC) and ovarian (OC) cancer. MiR-155, regulated by BRCA1, is a multifunctional microRNA that plays a crucial role in the immune system. The present study assessed… read more here.
Keywords: mir 155; cancer risk; cancer; brca1 methylation ... See more keywords
Comments on: Peripheral blood BRCA1 methylation profiling to predict familial ovarian cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Gynecologic Oncology"
DOI: 10.3802/jgo.2021.32.e33
Abstract: https://ejgo.org It is well recognized that approximately 20% of ovarian cancer cases can be attributed to pathogenic variants in BRCA1/2 [1,2]. Therefore, the majority of ovarian cancer cases must be associated with other genetic or… read more here.
Keywords: cancer; ovarian cancer; blood; brca1 methylation ... See more keywords