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Published in 2018 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2018.0211
Abstract: Importance Prophylactic bilateral salpingo-oophorectomy is recommended for BRCA1 mutation carriers to prevent ovarian cancer. Whether or not hormone replacement therapy (HRT) initiated after oophorectomy is associated with an increased risk of breast cancer has not…
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Keywords:
brca1 mutation;
breast cancer;
hrt;
cancer ... See more keywords
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Published in 2017 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-017-4123-x
Abstract: PurposeWomen who are newly diagnosed with breast cancer may consider contralateral prophylactic mastectomy (CPM) to reduce their future risk of cancer in their unaffected breast. Pre-surgical BRCA1/2 genetic testing can provide valuable risk information to…
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Keywords:
cpm;
breast cancer;
brca1 mutation;
mutation noncarriers ... See more keywords
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Published in 2021 at "Cirugia espanola"
DOI: 10.1016/j.cireng.2021.06.014
Abstract: Risk-reducing surgeries decrease the risk of developing breast cancer by 95%. But this type of surgery can be life-changing. This systematic review analyzed anxiety/depressive symptomatology, body image and quality of life on BRCA1/2 mutation carriers…
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Keywords:
symptomatology;
risk reducing;
mutation carriers;
brca1 mutation ... See more keywords
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Published in 2018 at "Clinical Breast Cancer"
DOI: 10.1016/j.clbc.2018.02.007
Abstract: Introduction We investigated the relative risk of breast and ovarian cancers related to the putative functional domain regions, obesity, and parity among Korean BRCA1/2 mutation carriers. Patients and Methods We analyzed the clinical characteristics, cancer…
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Keywords:
risk;
mutation carriers;
breast;
brca1 mutation ... See more keywords
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Published in 2019 at "European journal of cancer"
DOI: 10.1016/j.ejca.2018.10.022
Abstract: PURPOSE The presence of pathogenic germline mutation in BRCA1 gene is considered as the most penetrant genetic predisposition for breast cancer. However, a portion of BRCA1 mutation carriers never develops breast cancer throughout their lifetime.…
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Keywords:
mutation carriers;
breast cancer;
brca1 mutation;
cancer ... See more keywords
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Published in 2020 at "Journal of cardiology"
DOI: 10.1016/j.jjcc.2020.11.005
Abstract: BACKGROUND BRCA1/2 mutation carriers are generally exposed to early menopause due to risk-reducing salpingo-oophorectomy (RRSO) around the age of 40 years. This risk-reducing intervention is based on a 10-40% life-time risk of ovarian cancer in…
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Keywords:
risk reducing;
mutation carriers;
subclinical atherosclerosis;
brca1 mutation ... See more keywords
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Published in 2018 at "Maturitas"
DOI: 10.1016/j.maturitas.2017.11.002
Abstract: OBJECTIVES To reduce the risk of ovarian cancer, BRCA1/2 mutation carriers are advised to undergo salpingo-oophorectomy (RRSO) around the age of 40 years. This may induce severe climacteric symptoms, potentially lowering their quality of life.…
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Keywords:
physical fitness;
mutation carriers;
self compassion;
brca1 mutation ... See more keywords
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Published in 2019 at "Translational Oncology"
DOI: 10.1016/j.tranon.2019.11.003
Abstract: Ovarian cancer (OC) is an important cause of gynecologic cancer-related deaths. In Mexico, around 4700 new cases of OC are diagnosed per year and it represents the second cause of gynecological cancer mortality with more…
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Keywords:
mutation mexican;
brca1 mutation;
ovarian cancer;
cancer ... See more keywords
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Published in 2022 at "BMJ Case Reports"
DOI: 10.1136/bcr-2022-249370
Abstract: A woman in her 50s previously treated for early-stage breast cancer, parotid mucoepidermoid carcinoma and Caroli’s disease was diagnosed with stage IV pancreatic ductal adenocarcinoma (PDAC) metastatic to the liver and was found to harbour…
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Keywords:
brca1;
response brca1;
adenocarcinoma;
response ... See more keywords
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Published in 2018 at "BMJ Open"
DOI: 10.1136/bmjopen-2018-023115
Abstract: Introduction BRCA1 mutation carriers have a significant lifetime risk of breast cancer, with their primary risk-reduction option being bilateral mastectomy. Preclinical work from our laboratory demonstrated that in BRCA1-deficient breast cells, oestrogen and its metabolites…
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Keywords:
trial;
mutation carriers;
treatment;
brca1 ... See more keywords
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Published in 2021 at "Oncology"
DOI: 10.1159/000515790
Abstract: Purpose: The BRCA1/2 gene is the most well-known and studied gene associated with hereditary breast cancer. BRCA1/2 genetic testing is widely performed in high-risk patients of hereditary breast cancer in Korea. This study aimed to…
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Keywords:
cancer;
brca1 mutation;
breast cancer;