Prevalence of Germline BRCA1/2 Variants in Ashkenazi and Non-Ashkenazi Prostate Cancer Populations: A Systematic Review and Meta-Analysis
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DOI: 10.3390/cancers15010306
Abstract: Simple Summary Germline BRCA2 pathogenic variant carriers are associated with prostate cancer risk. Ashkenazi Jewish people are at higher risk of breast cancer due to the high prevalence of specific founder germline BRCA1/2 variants. The… read more here.
Keywords: prostate cancer; germline brca1; non ashkenazi; brca1 variants ... See more keywords
Consolidated BRCA1/2 Variant Interpretation by MH BRCA Correlates with Predicted PARP Inhibitor Efficacy Association by MH Guide
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DOI: 10.3390/ijms21113895
Abstract: BRCA1/2 variants are prognostic biomarkers for hereditary breast and/or ovarian cancer (HBOC) syndrome and predictive biomarkers for PARP inhibition. In this study, we benchmarked the classification of BRCA1/2 variants from patients with HBOC-related cancer using… read more here.
Keywords: inhibitor efficacy; brca1 variants; brca1; efficacy ... See more keywords