A comprehensive analysis of BRCA2 gene: focus on mechanistic aspects of its functions, spectrum of deleterious mutations, and therapeutic strategies targeting BRCA2-deficient tumors
Sign Up to like & getrecommendations! Published in 2018 at "Medical Oncology"
DOI: 10.1007/s12032-018-1085-8
Abstract: BRCA2is the main susceptibility gene known to be involved in the pathogenesis of breast cancer. It plays an important role in maintaining the genome stability by homologous recombination through DNA double-strand breaks repairing, by interacting… read more here.
Keywords: deficient tumors; brca2; brca2 deficient; brca2 gene ... See more keywords
FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments.
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DOI: 10.1126/science.adt1210
Abstract: Homologous recombination (HR) deficiency upon Breast Cancer Gene 2 (BRCA2) loss arises from defects in the formation of RAD51 nucleoprotein filaments. We demonstrate that loss of the anti-recombinase Fidgetin Like 1 (FIGNL1) retains RAD51 loading… read more here.
Keywords: deficient cells; homologous recombination; deficient; rad51 ... See more keywords
Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.80254
Abstract: The trapping of Poly-ADP-ribose polymerase (PARP) on DNA caused by PARP inhibitors (PARPi) triggers acute DNA replication stress and synthetic lethality (SL) in BRCA2-deficient cells. Hence, DNA damage is accepted as a prerequisite for SL… read more here.
Keywords: brca2 deficient; synthetic lethality; lethality brca2; deficient cells ... See more keywords