A comprehensive analysis of BRCA2 gene: focus on mechanistic aspects of its functions, spectrum of deleterious mutations, and therapeutic strategies targeting BRCA2-deficient tumors
Sign Up to like & getrecommendations! Published in 2018 at "Medical Oncology"
DOI: 10.1007/s12032-018-1085-8
Abstract: BRCA2is the main susceptibility gene known to be involved in the pathogenesis of breast cancer. It plays an important role in maintaining the genome stability by homologous recombination through DNA double-strand breaks repairing, by interacting… read more here.
Keywords: deficient tumors; brca2; brca2 deficient; brca2 gene ... See more keywords
Association of BRCA2 Gene Functional Polymorphisms with Nonsyndromic Cleft Lip With or Without Cleft Palate in a Chinese Population.
Sign Up to like & getrecommendations! Published in 2023 at "Genetic testing and molecular biomarkers"
DOI: 10.1089/gtmb.2022.0223
Abstract: Background: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a complex congenital disease affected by gene and environmental factors. Hereditary factors play an important role; however, its specific pathogenic genes and regulatory mechanisms… read more here.
Keywords: nonsyndromic cleft; gene; chinese population; brca2 gene ... See more keywords
BRCA2 gene mutation in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000031705
Abstract: Breast cancer susceptibility gene 2 (BRCA2) is the main gene associated with hereditary breast cancers. However, a mutation in BRCA2 has also been found in other tumors, such as ovarian, pancreatic, thyroid, gastric, laryngeal, and… read more here.
Keywords: gene mutation; brca2; brca2 gene; gene ... See more keywords
BRCA2 gene mutation and prostate cancer risk. Comprehensive review and update.
Sign Up to like & getrecommendations! Published in 2020 at "Saudi medical journal"
DOI: 10.15537/smj.2020.1.24759
Abstract: The second most common type of tumor worldwide is prostate cancer (PCa). Certain genetic factors contribute to a risk of developing PCa of as much as 40%. BRCA1 and BRCA2 mutations have linked with an… read more here.
Keywords: risk; brca2 gene; prostate cancer; brca2 ... See more keywords
Identification of Variants (rs11571707, rs144848, and rs11571769) in the BRCA2 Gene Associated with Hereditary Breast Cancer in Indigenous Populations of the Brazilian Amazon
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12020142
Abstract: Estimates show that 5–10% of breast cancer cases are hereditary, caused by genetic variants in autosomal dominant genes; of these, 16% are due to germline mutations in the BRCA1 and BRCA2 genes. The comprehension of… read more here.
Keywords: cancer; hereditary breast; brca2 gene; breast cancer ... See more keywords