The association between smoking and cancer incidence in BRCA1 and BRCA2 mutation carriers
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31257
Abstract: Tobacco smoke is an established carcinogen, but the association between tobacco smoking and cancer risk in BRCA mutation carriers is not clear. The aim of this study was to evaluate prospectively the association between tobacco… read more here.
Keywords: mutation carriers; brca1 brca2; smoking cancer; cancer ... See more keywords
Effect of cisplatin on metastatic castration-resistant prostate cancer with BRCA2 mutation: A case report
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DOI: 10.1016/j.eucr.2021.101712
Abstract: Poly (ADP-ribose) polymerase inhibitors exhibit strong activity for treating the DNA damage repair defect in patients with prostate carcinoma (PCa). Although conventional DNA-damaging agents can theoretically lead to synthetic antitumoral effects, no report has clearly… read more here.
Keywords: metastatic castration; castration resistant; cancer; brca2 mutation ... See more keywords
Oestrogen receptor status and survival in women with BRCA2-associated breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Cancer"
DOI: 10.1038/s41416-019-0376-y
Abstract: BackgroundTo evaluate the predictors of mortality, including ER status, in women with a BRCA2 mutation and breast cancer.MethodsEligible participants were identified from within two longitudinal cohorts. These patients were selected because they were diagnosed with… read more here.
Keywords: status; breast cancer; cancer; women brca2 ... See more keywords
International trends in the uptake of cancer risk reduction strategies in women with a BRCA1 or BRCA2 mutation
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Cancer"
DOI: 10.1038/s41416-019-0446-1
Abstract: BackgroundWomen with a BRCA1 or BRCA2 mutation face high risks of breast and ovarian cancer. In the current study, we report on uptake of cancer screening and risk-reduction options in a cohort of BRCA mutation… read more here.
Keywords: uptake cancer; risk reduction; brca1 brca2; cancer ... See more keywords
Dramatic response of FOLFIRINOX regimen in a collision pancreatic adenocarcinoma patient with a germline BRCA2 mutation: a case report.
Sign Up to like & getrecommendations! Published in 2019 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyz141
Abstract: Germline BRCA1 and BRCA2 mutations are the most common gene mutations in familial pancreatic adenocarcinoma. Several reports have demonstrated the utility of platinum-based chemotherapy for treating cancer patients who harbour a BRCA mutation. Here we… read more here.
Keywords: germline brca2; adenocarcinoma; pancreatic adenocarcinoma; brca2 mutation ... See more keywords
Effect of the Combination of Trabectedin and Pegylated Liposomal Doxorubicin in a BRCA2 Mutation Carrier with Recurrent Platinum-Sensitive Ovarian Cancer
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DOI: 10.1159/000475707
Abstract: Introduction: The current standard of care for ovarian cancer is optimal cytoreduction with adjuvant chemotherapy based on a platinum/taxane combination. Although the response rate to this therapy is high, most patients ultimately relapse. Response to… read more here.
Keywords: chemotherapy; platinum; ovarian cancer; brca2 mutation ... See more keywords
Association betweenBRCA1 and BRCA2 mutations and prognosis in women with endometrial carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e17115
Abstract: e17115 Background: To evaluate the prognosis of BRCA mutation carriers compared to non-carriers and to demonstrate whether BRCA1 and BRCA2 mutation carriers present similar survival patterns among endometrial carcinomas. Methods: This data was from NCI… read more here.
Keywords: brca2 mutation; non carriers; brca1 brca2; mutation ... See more keywords
Estrogen Receptor Status Oppositely Modifies Breast Cancer Prognosis in BRCA1/BRCA2 Mutation Carriers Versus Non-Carriers
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DOI: 10.3390/cancers11060738
Abstract: Breast cancer (BC) prognosis in BRCA1 and BRCA2 mutation carriers has been reported contradictorily, and the significance of variables influencing prognosis in sporadic BC is not established in BC patients with hereditary BRCA1/BRCA2 mutations. In… read more here.
Keywords: mutation carriers; non carriers; brca2; brca1 brca2 ... See more keywords